Results 91 to 100 of about 126,794,803 (294)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

4-H Group Pets Horse at Milky Way Farms

, 1986
A group of young 4-H members pet a horse at Cecil Reagan's Milky Ways Farms.
The Bradenton Herald
core  

Fermi-bubble Bulk and Edge Analysis Reveals Dust, Cooling Breaks, and Cosmic-Ray Diffusion, Facilitating a Self-consistent Model

The Astrophysical Journal
The full, radio to γ -ray spectrum of the Fermi bubbles is shown to be consistent with standard strong-shock electron acceleration at the bubble edge, without the unnatural energy cutoffs and unrealistic electron cooling of previous studies, if the ...
Uri Keshet, Ilya Gurwich, Assaf Lavi, Dina Avitan, Teodor Linnik   +4 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

4-H Group Visiting Cows at Milky Way Farm

, 1986
A group of young 4-H members visit the cows at Cecil Reagan's Milky Ways Farms. The farm was in operation on Upper Manatee River Road from 1954 to 1992.
The Bradenton Herald
core  

Milky Way Morphology [PDF]

, 2019
From our limited perspective—living on a planet that orbits one of several hundred billion stars inside the Milky Way—the detailed structure of our home galaxy is difficult to determine.
Marschall, Laurence A.
core   +1 more source

Measurement of Dependence of Microlensing Planet Frequency on the Host Star Mass and Galactocentric Distance by Using a Galactic Model

The Astrophysical Journal
We measure the dependence of planet frequency on host star mass, M _L , and distance from the Galactic center, R _L , using a sample of planets discovered by gravitational microlensing.
Kansuke Nunota, Naoki Koshimoto, Daisuke Suzuki, Takahiro Sumi, David P. Bennett, Aparna Bhattacharya, Yuki Hirao, Sean K. Terry, Aikaterini Vandorou   +8 more
doaj   +1 more source

Constraining the formation of the Milky Way: Ages

EPJ Web of Conferences, 2013
We present a new approach for studying the chemodynamical evolution of the Milky Way, which combines a thin disk chemical evolution model with the dynamics from N-body simulation of a galaxy with properties similar to those of our Galaxy.
Martig M., Minchev I., Chiappini C.
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source