Results 91 to 100 of about 134,673,186 (290)

The superclouds of the local Milky Way

Astronomy & Astrophysics
Recent 3D dust maps of the local Milky Way are revolutionizing our understanding of the Sun’s Galactic neighborhood, providing much needed insight into the large-scale organization of the interstellar medium.
Kormann Lilly A., Alves João, Pantaleoni González Michelangelo, Swiggum Cameren, Enßlin Torsten A., Edenhofer Gordian   +5 more
doaj   +1 more source

Fountain-driven gas accretion by the Milky Way

EPJ Web of Conferences, 2012
Accretion of fresh gas at a rate of ∼ 1M☉yr−1 is necessary in star-forming disc galaxies, such as the Milky Way, in order to sustain their star-formation rates.
Ciotti L., Nipoti C., Binney J., Fraternali F., Marinacci F., Londrillo P.   +5 more
doaj   +1 more source

A Precise Milky Way

, 2018
The Milky Way Galaxy in which we live seems to be a normal spiral galaxy. But it can be hard to tell. Our perspective from within it precludes a "face-on" view like the picture above, which combines some real data with a lot of artistic liberty.
Stacy McGaugh
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

The accretion history of the Milky Way

Astronomy & Astrophysics
Several studies have associated globular clusters (GCs) with former Galactic accretion events by comparing their positions in the energy-angular momentum (E-Lz) plane, an approach further supported by similarities in their age-metallicity relations ...
Akib Istiak, Hammer François, Yang Yanbin   +2 more
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Measurement of Dependence of Microlensing Planet Frequency on the Host Star Mass and Galactocentric Distance by Using a Galactic Model

The Astrophysical Journal
We measure the dependence of planet frequency on host star mass, M _L , and distance from the Galactic center, R _L , using a sample of planets discovered by gravitational microlensing.
Kansuke Nunota, Naoki Koshimoto, Daisuke Suzuki, Takahiro Sumi, David P. Bennett, Aparna Bhattacharya, Yuki Hirao, Sean K. Terry, Aikaterini Vandorou   +8 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Fermi-bubble Bulk and Edge Analysis Reveals Dust, Cooling Breaks, and Cosmic-Ray Diffusion, Facilitating a Self-consistent Model

The Astrophysical Journal
The full, radio to γ -ray spectrum of the Fermi bubbles is shown to be consistent with standard strong-shock electron acceleration at the bubble edge, without the unnatural energy cutoffs and unrealistic electron cooling of previous studies, if the ...
Uri Keshet, Ilya Gurwich, Assaf Lavi, Dina Avitan, Teodor Linnik   +4 more
doaj   +1 more source

Constraining the formation of the Milky Way: Ages

EPJ Web of Conferences, 2013
We present a new approach for studying the chemodynamical evolution of the Milky Way, which combines a thin disk chemical evolution model with the dynamics from N-body simulation of a galaxy with properties similar to those of our Galaxy.
Martig M., Minchev I., Chiappini C.
doaj   +1 more source