Results 21 to 30 of about 134,673,186 (290)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Deciphering the Kinematic Substructure of Local Dark Matter with LAMOST K Giants

The Astrophysical Journal
Numerical simulations indicate that correlations exist between the velocity distributions of stars and dark matter (DM). We study the local DM velocity distribution based on these correlations.
Hai Zhu, Rui Guo, Juntai Shen, Jianglai Liu, Chao Liu, Xiang-Xiang Xue, Lan Zhang, Shude Mao   +7 more
doaj   +1 more source

What Does the Milky Way Look Like?

The Astrophysical Journal, 2023
In spite of much work, the overall spiral structure morphology of the Milky Way remains somewhat uncertain. In the last two decades, accurate distance measurements have provided us with an opportunity to solve this issue.
Y. Xu, C. J. Hao, D. J. Liu, Z. H. Lin, S. B. Bian, L. G. Hou, J. J. Li, Y. J. Li   +7 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Constraining the Milky Way Halo Accretion History with Simulated Stellar Halos: Designing the HALO7D-X Survey

The Astrophysical Journal
We present the design for HALO7D-X, a survey of the stellar halo to investigate the accretion history of the Milky Way. The survey will use a combination of Hubble Space Telescope (HST) and Gaia data for sky position and proper motions of faint stars (18 
Miranda Apfel, Kevin McKinnon, Constance M. Rockosi, Puragra Guhathakurta, Kathryn V. Johnston   +4 more
doaj   +1 more source

Overview of the DESI Milky Way Survey

The Astrophysical Journal, 2023
We describe the Milky Way Survey (MWS) that will be undertaken with the Dark Energy Spectroscopic Instrument (DESI) on the Mayall 4 m telescope at the Kitt Peak National Observatory.
Andrew P. Cooper, Sergey E. Koposov, Carlos Allende Prieto, Christopher J. Manser, Namitha Kizhuprakkat, Adam D. Myers, Arjun Dey, Boris T. Gänsicke, Ting S. Li, Constance Rockosi, Monica Valluri, Joan Najita, Alis Deason, Anand Raichoor, M.-Y. Wang, Y.-S. Ting, Bokyoung Kim, Andreia Carrillo, Wenting Wang, Leandro Beraldo e Silva, Jiwon Jesse Han, Jiani Ding, Miguel Sánchez-Conde, Jessica N. Aguilar, Steven Ahlen, Stephen Bailey, Vasily Belokurov, David Brooks, Katia Cunha, Kyle Dawson, Axel de la Macorra, Peter Doel, Daniel J. Eisenstein, Parker Fagrelius, Kevin Fanning, Andreu Font-Ribera, Jaime E. Forero-Romero, Enrique Gaztañaga, Satya Gontcho A Gontcho, Julien Guy, Klaus Honscheid, Robert Kehoe, Theodore Kisner, Anthony Kremin, Martin Landriau, Michael E. Levi, Paul Martini, Aaron M. Meisner, Ramon Miquel, John Moustakas, Jundan J. D. Nie, Nathalie Palanque-Delabrouille, Will J. Percival, Claire Poppett, Francisco Prada, Nabeel Rehemtulla, Edward Schlafly, David Schlegel, Michael Schubnell, Ray M. Sharples, Gregory Tarlé, Risa H. Wechsler, David H. Weinberg, Zhimin Zhou, Hu Zou   +64 more
doaj   +1 more source

TRILEGAL, a TRIdimensional modeL of thE GALaxy: Status and FutureRed Giants as Probes of the Structure and Evolution of the Milky Way

, 2012
We briefly describe TRILEGAL, a TRIdimensional modeL of thE GALaxy, and its more recent developments. Particularly relevant is the recent inclusion of a kinematical module to the code, and the present efforts to provide a more solid calibration of Milky ...
Barbieri, Mauro, Groenewegen, Martin A. T., Santiago, Basílio X., da Costa, Luiz N., Bressan, Alessandro, Rocha Pinto, Helio J., Camargo, Julio I. B., Girardi, Léo, MARIGO, PAOLA   +8 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Chemodynamical evolution of the Milky Way

, 2003
We simulate the chemodynamical evolution of the Milky Way using our GRAPE-SPH code, and reproduce the age-metallicity relation, the [O/Fe]-[Fe/H] relation, and the metallicity ...
Nomoto, K., Nakasato, N., Kobayashi, C.
core   +4 more sources

The Rapid Formation of the Metal-poor Milky Way

The Astrophysical Journal
Our understanding of the assembly timeline of the Milky Way has been transforming along with the dramatic increase in astrometric and spectroscopic data available over the past several years.
Rebecca Woody, Charlie Conroy, Phillip Cargile, Ana Bonaca, Vedant Chandra, Jiwon Jesse Han, Benjamin D. Johnson, Rohan P. Naidu, Yuan-Sen Ting   +8 more
doaj   +1 more source