Results 31 to 40 of about 134,673,186 (290)
A study of radio continuum emission of the Milky Way Galaxy [PDF]
, 1996 The synchrotron emissivity distribution of the Milky Way Galaxy has been modelled from the 408 MHz allsky survey of Haslam et al.(1982) after separation of its thermal component with the help of IRAS 60 micron emission(Broadbent et al 1989).
Sanguansak, Nuanwan
core
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
The Astrophysical JournalMilky Way analogs (MWAs) have long been studied by astronomers to place our Galaxy within an extragalactic context. With the power of cosmological simulations, we are now able to not only characterize MWAs today, but also watch as they evolve through ...
Alicia M. Savelli +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Minimum-entropy Constraints on Galactic Potentials
The Astrophysical JournalA tracer sample in a gravitational potential, starting from a generic initial condition, phase-mixes toward a stationary state. This evolution is accompanied by an entropy increase, and the final state is characterized by a distribution function (DF ...
Leandro Beraldo e Silva +5 more
doaj +1 more source
Stellar abundances in clusters: High-resolution, multi-object spectroscopy of globular & open clusters in the Milky Way [PDF]
, 2015 Talk on high-resolution, multi-object spectroscopy of globular & open clusters in the Milky ...
BRAGAGLIA, Angela
core
ORIGIN AND EVOLUTION OF THE ABUNDANCE GRADIENT ALONG THE MILKY WAY DISK
, 2009 Based on a simple model of the chemical evolution of the Milky Way disk, we investigate the disk oxygen abundance gradient and its time evolution. Two star formation rates (SFRs) are considered, one is the classical Kennicutt-Schmidt law (Psi = 0.25 ...
Chang, R. X. +3 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Synthetic Gaia DR3 Surveys from the FIRE Cosmological Simulations of Milky Way-mass Galaxies
The Astrophysical JournalThe third data release (DR3) of Gaia has provided a fivefold increase in the number of radial velocity measurements of stars, as well as a stark improvement in parallax and proper motion measurements.
Tri Nguyen +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source