Results 31 to 40 of about 146,005 (284)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Rapid Formation of the Metal-poor Milky Way

The Astrophysical Journal
Our understanding of the assembly timeline of the Milky Way has been transforming along with the dramatic increase in astrometric and spectroscopic data available over the past several years.
Turner Woody, Charlie Conroy, Phillip Cargile, Ana Bonaca, Vedant Chandra, Jiwon Jesse Han, Benjamin D. Johnson, Rohan P. Naidu, Yuan-Sen Ting   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

SF-R You Sure? The Conflicting Role of Star Formation Rates in Constraining the Evolution of Milky Way Analogs in Cosmological Simulations

The Astrophysical Journal
Milky Way analogs (MWAs) have long been studied by astronomers to place our Galaxy within an extragalactic context. With the power of cosmological simulations, we are now able to not only characterize MWAs today, but also watch as they evolve through ...
Alicia M. Savelli, Joshua S. Speagle, J. Ted Mackereth, Norman Murray, Kartheik G. Iyer   +4 more
doaj   +1 more source

The Dark Disk of the Milky Way

, 2009
Massive satellite accretions onto early galactic disks can lead to the deposition of dark matter in disk-like configurations that co-rotate with the galaxy. This phenomenon has potentially dramatic consequences for dark matter detection experiments.
Bruch, Chris W. Purcell, Conroy, Gilmore, Gomez, Hammer, James S. Bullock, Jurić, Kazantzidis, Manoj Kaplinghat, Moster, Purcell, Purcell, Stewart, Widrow, Wyse   +15 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Minimum-entropy Constraints on Galactic Potentials

The Astrophysical Journal
A tracer sample in a gravitational potential, starting from a generic initial condition, phase-mixes toward a stationary state. This evolution is accompanied by an entropy increase, and the final state is characterized by a distribution function (DF ...
Leandro Beraldo e Silva, Monica Valluri, Eugene Vasiliev, Kohei Hattori, Walter de Siqueira Pedra, Kathryne J. Daniel   +5 more
doaj   +1 more source

Modelling the HI halo of the Milky Way [PDF]

, 2010
Aims: we studied the global distribution and kinematics of the extra-planar neutral gas in the Milky Way. Methods: we built 3D models for a series of Galactic HI layers, projected them for an inside view, and compared them with the Leiden-Argentina-Bonn ...
A. Marasco, Bajaja, Binney, Boomsma, Boomsma, Bregman, Celnik, Collins, F. Fraternali, Ford, Fraternali, Fraternali, Fraternali, Fraternali, Fraternali, Fraternali, Habing, Heald, Heald, Kalberla, Kalberla, Kalberla, Kamphuis, Kamphuis, Kaufmann, Kerr, Kerr, Levine, Levine, Lockman, Lockman, Lockman, Malhotra, Marinacci, Marinacci, McClure-Griffiths, Münch, Oort, Oosterloo, Pidopryhora, Reid, Reynolds, Rossa, Sancisi, Sembach, Shane, Shapiro, Smith, Spitzer, Stil, Thilker, Thom, Tripp, Wakker, Wakker, Wakker, Wakker, Wakker, Wakker   +58 more
core   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Synthetic Gaia DR3 Surveys from the FIRE Cosmological Simulations of Milky Way-mass Galaxies

The Astrophysical Journal
The third data release (DR3) of Gaia has provided a fivefold increase in the number of radial velocity measurements of stars, as well as a stark improvement in parallax and proper motion measurements.
Tri Nguyen, Xiaowei Ou, Nondh Panithanpaisal, Nora Shipp, Lina Necib, Robyn Sanderson, Andrew Wetzel   +6 more
doaj   +1 more source