Results 41 to 50 of about 134,673,186 (290)

Estimating the Initial Mass of the Gaia–Enceladus Dwarf Galaxy with a Chemical Evolution Model

The Astrophysical Journal
This work investigates the initial mass and chemical evolution history of the Gaia–Enceladus dwarf galaxy. We combine spectroscopic data from APOGEE with astrometric data from Gaia Data Release 3 to identify Gaia–Enceladus candidate stars via a machine ...
Olcay Plevne, Furkan Akbaba
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

What Is Missing from the Local Stellar Halo?

The Astrophysical Journal
The Milky Way’s stellar halo, which extends to >100 kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kiloparsecs of the Sun.
Katherine Sharpe, Rohan P. Naidu, Charlie Conroy   +2 more
doaj   +1 more source

Simulating the Milky Way is hard

EPJ Web of Conferences, 2012
The formation of the Milky Way in the currently accepted concordance cosmology presents a couple of pitfalls. Mostly, these involve the much reported overcooling problem.
Stinson G., Brook C.
doaj   +1 more source

AuriDESI: mock catalogues for the DESI Milky Way Survey [PDF]

The Dark Energy Spectroscopic Instrument Milky Way Survey (DESI MWS) will explore the assembly history of the Milky Way by characterizing remnants of ancient dwarf galaxy accretion events and improving constraints on the distribution of dark matter in ...
de la Macorra, Axel, Ahlen, Steven, Claybaugh, Todd, Meisner, Aaron, Koposov, Sergey E, Rezaie, Mehdi, Zhou, Zhimin, Manera, Marc, Grand, Robert J J, Kizhuprakkat, Namitha, Honscheid, Klaus, Cooper, Andrew P, Dawson, Kyle, Schubnell, Michael, Tarlé, Gregory, Brooks, David, Landriau, Martin, Allende Prieto, Carlos, Seo, Hee-Jong, Nie, Jundan, Rossi, Graziano, Valluri, Monica, Miquel, Ramon, Gaztañaga, Enrique, Gontcho A Gontcho, Satya, Frenk, Carlos, Prada, Francisco, Sanchez, Eusebio, Kehoe, Robert, Aguilar, Jessica Nicole, Gnedin, Oleg Y, Riley, Alexander H, Doel, Peter, Forero-Romero, Jaime E, de la Macorra, A, Riley, Alexander H., Grand, Robert J. J., Grand, RJJ, Gaztañaga, E, Cooper, AP, Zhou, Z, Forero-Romero, JE, Prada, F, Miquel, R, Claybaugh, T, Schubnell, M, Seo, HJ, Manera, M, Forero-Romero, Jaime E., Koposov, SE, Frenk, C, Gnedin, Oleg Y., Honscheid, K, Sanchez, E, Gnedin, OY, Landriau, M, Rezaie, M, Nie, J, Prieto, Carlos Allende, Kehoe, R, Prieto, CA, Cooper, Andrew P., Tarlé, G, Brooks, D, Doel, P, Gontcho, SGA, Kizhuprakkat, N, Meisner, A, Koposov, Sergey E., Dawson, K, Valluri, M, Ahlen, S, Gontcho, Satya Gontcho A, Rossi, G, Aguilar, JN, Riley, AH   +75 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Orbital Torus Imaging: Acceleration, Density, and Dark Matter in the Galactic Disk Measured with Element Abundance Gradients

The Astrophysical Journal
Under the assumption of a simple and time-invariant gravitational potential, many Galactic dynamics techniques infer the milky Way’s mass and dark matter distributions from stellar kinematic observations.
Danny Horta, Adrian M. Price-Whelan, David W. Hogg, Kathryn V. Johnston, Lawrence Widrow, Julianne J. Dalcanton, Melissa K. Ness, Jason A. S. Hunt   +7 more
doaj   +1 more source

Milky Way reionisation with GAMESH

, 2018
Talk done at DAVID Meeting 2014 on MIlky Way ...
Luca Graziani, Luca Graziani (6005609)
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Watching Our Galaxy Grow Up: The Mass and Color Evolution of the Milky Way

The Astrophysical Journal
Using our rich observations within the Milky Way to better understand galaxy evolution requires understanding what the Milky Way looks like “as a galaxy”—that is, its “true” shape and abundance profiles (unskewed by observational biases), signatures of ...
Gail Zasowski, Julie Imig, Hayley Coluccio   +2 more
doaj   +1 more source