Results 41 to 50 of about 146,005 (284)

Predicting the locations of possible long-lived low-mass first stars: Importance of satellite dwarf galaxies

, 2017
The search for metal-free stars has so far been unsuccessful, proving that if there are surviving stars from the first generation, they are rare, they have been polluted, or we have been looking in the wrong place.
Agarwal, Bhaskar, Frebel, Anna, Glover, Simon C. O., Griffen, Brendan F., Hartwig, Tilman, Klessen, Ralf S., Magg, Mattis   +6 more
core   +3 more sources

The origin of the Milky Way globular clusters [PDF]

, 2016
We present a cosmological zoom-in simulation of a Milky Way-like galaxy used to explore the formation and evolution of star clusters. We investigate in particular the origin of the bimodality observed in the colour and metallicity of globular clusters ...
Agertz, Oscar, Gieles, Mark, Renaud, Florent   +2 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Estimating the Initial Mass of the Gaia–Enceladus Dwarf Galaxy with a Chemical Evolution Model

The Astrophysical Journal
This work investigates the initial mass and chemical evolution history of the Gaia–Enceladus dwarf galaxy. We combine spectroscopic data from APOGEE with astrometric data from Gaia Data Release 3 to identify Gaia–Enceladus candidate stars via a machine ...
Olcay Plevne, Furkan Akbaba
doaj   +1 more source

Simulating the Milky Way is hard

EPJ Web of Conferences, 2012
The formation of the Milky Way in the currently accepted concordance cosmology presents a couple of pitfalls. Mostly, these involve the much reported overcooling problem.
Stinson G., Brook C.
doaj   +1 more source

Dense Gas in the Milky Way [PDF]

, 1996
We present a study of dense gas emission in the Milky Way in order to serve as a basis for comparison with extragalactic results. This study combines new observations of HCN, CS, and CO in individual GMCs and in the Milky Way plane with published studies
Leo Blitz, Liszt H. S., Tamara T. Helfer
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

What Is Missing from the Local Stellar Halo?

The Astrophysical Journal
The Milky Way’s stellar halo, which extends to >100 kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kiloparsecs of the Sun.
Katherine Sharpe, Rohan P. Naidu, Charlie Conroy   +2 more
doaj   +1 more source

Rotation curve of the Milky Way

EPJ Web of Conferences, 2012
We use SEGUE and Hipparcos data to restrict the behaviour of the rotation curve of the Milky Way in the solar neighbourhood. Then we construct a density model of the Milky Way which best reproduces the available observations of the rotation curve and is ...
Lee Y.S., Beers T.C., Just A., Golubov O.   +3 more
doaj   +1 more source

The Age of the Milky Way Inner Halo

, 2012
The Milky Way galaxy is observed to have multiple components with distinct properties, such as the bulge, disk, and halo. Unraveling the assembly history of these populations provides a powerful test to the theory of galaxy formation and evolution, but ...
A Dotter, A Dotter, A Dotter, A Renzini, A Sarajedini, A Zolotov, AS Font, B Paczyński, BR Oppenheimer, D Carollo, DR Soderblom, E Gates, E-M Pauli, G Wegner, Jason S. Kalirai, JS Kalirai, JS Kalirai, JS Kalirai, JS Kalirai, LR Bedin, M Kilic, P Bergeron, P Jofré, P-E Tremblay, P-E Tremblay, R Napiwotzki, S Moehler, SL Shapiro, TC Beers   +28 more
core   +1 more source