Results 51 to 60 of about 32,046 (262)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
He Awa Whiria: The Tidal Streams of Interstellar Objects
The Astrophysical JournalUpcoming surveys are likely to discover a new sample of interstellar objects (ISOs) within the solar system, but questions remain about the origin and distribution of this population within the Galaxy.
John C. Forbes +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The Astrophysical Journal LettersStellar mass is the most fundamental property of a galaxy. While it has been robustly measured for millions of external galaxies, it remains poorly constrained for the Milky Way because of the strong selection effect from our inside perspective.
Jianhui Lian +4 more
doaj +1 more source
The Mass of the Milky Way Galaxy
, 2023 On the Basis of tabular values of the gravitational constant. The calculated mass of the nucleus of the milky way galaxy. The numerical value of the gravitational constant is determined by the mass of the nucleus of the milky way galaxy.
Shavkyatovich, Yanbikov Vildan
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Gaussian Process Methods for Very Large Astrometric Data Sets
The Astrophysical JournalWe present a novel nonparametric method for inferring smooth models of the mean velocity field and velocity dispersion tensor of the Milky Way from astrometric data.
Timothy Hapitas +3 more
doaj +1 more source
, 2011 We present the first systematic comparison of the detailed properties, including internal kinematics, chemical abundances, sizes, and dark matter masses, of Milky Way and M 31 dSphs as a part of the SPLASH Survey (Spectroscopic and Photometric Landscape ...
R.J. Patterson +9 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source