Results 51 to 60 of about 134,673,186 (290)

4MOST Consortium Survey 3: Milky Way disc and bulge low-resolution survey (4MIDABLE-LR)

, 2019
The mechanisms of the formation and evolution of the Milky Way are encoded in the orbits, chemistry and ages of its stars. With the 4MOST MIlky way Disk And BuLgE Low-Resolution Survey (4MIDABLE-LR) we aim to study kinematic and chemical substructures in
Feltzing, S., Kovalev, M., Rix, H., Monari, G., Fouesneau, M., Ryde, N., Traven, G., Storm, J., Fusillo, N.~G., Tremblay, P., Xiang, M., Khalatyan, A., Casagrande, L., Lemasle, B., Asplund, M., Queiroz, A.~B.~D.~A., Fusillo, N., Kordopatis, G., Zucker, D., Steinmetz, M., Bensby, T., Cescutti, G., de Queiroz, A., Minchev, I., Schwope, A., Matijevic, G., Bergemann, M., McMillan, P., Anders, F., Church, R., Walton, N., Gerhard, O., Arentsen, A., Tremblay, P. -E., Chiappini, C., Grebel, E.~K., Team, 4MIDABLE-Lr, Guiglion, G., Rybizki, J., Queiroz, A., Starkenburg, E., Valentini, M., Team, 4., Rix, H. -W., Andrae, R., Grebel, E., McMillan, P.,, Church, R.,, Bensby, T.,, Lund University., Feltzing, S.,, Traven, G.,, Ryde, N.,   +52 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Rising from the Ashes: A Metallicity-dependent Star Formation Gap Splits the Milky Way’s α Sequences

The Astrophysical Journal
The elemental abundance distribution of stars encodes the history of the gas-phase abundance in the Milky Way. Without a large, unbiased sample of highly precise stellar ages, the exact timing and nature of this history must be inferred from the ...
Angus Beane
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Galactic Chemical Evolution Models Favor an Extended Type Ia Supernova Delay-time Distribution

The Astrophysical Journal
Type Ia supernovae (SNe Ia) produce most of the Fe-peak elements in the Universe and therefore are a crucial ingredient in galactic chemical evolution models.
Liam O. Dubay, Jennifer A. Johnson, James W. Johnson   +2 more
doaj   +1 more source

The Milky Way bulge

This chapter reviews the three-dimensional structure, age, kinematics, and chemistry of the Milky Way (MW) region within ~2 kpc from its center (hereafter referred to as the 'bulge') from an observational perspective. While not exhaustive in citations, this review provides historical context and discusses the main controversies and limitations in the ...
Zoccali, Manuela, Valenti, Elena
openaire   +3 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The Milky Way Is a Less Massive Galaxy—New Estimates of the Milky Way’s Local and Global Stellar Masses

The Astrophysical Journal Letters
Stellar mass is the most fundamental property of a galaxy. While it has been robustly measured for millions of external galaxies, it remains poorly constrained for the Milky Way because of the strong selection effect from our inside perspective.
Jianhui Lian, Tao Wang, Qikang Feng, Yang Huang, Helong Guo   +4 more
doaj   +1 more source

Milky Way Project DR1 Large Bubble Catalogue

, 2012
Catalogue of large bubbles released a apart of the Milky Way Project (Zooniverse) first data release.
Robert Simpson (97208)
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source