Results 61 to 70 of about 32,046 (262)
On the Formation of Planets in the Milky Way’s Thick Disk
The Astrophysical JournalExoplanet demographic surveys have revealed that close-in (≲1 au) small planets orbiting stars in the Milky Way’s thick disk are ∼50% less abundant than those orbiting stars in the Galactic thin disk.
Tim Hallatt, Eve J. Lee
doaj +1 more source
Planetary nebulae beyond the milky way - Historical overview [PDF]
, 2006 Up to 10% of the total luminosity of a planetary nebula, ~500 L⊙, can be emitted in the dominant cooling line, [O iii] λ5007. This, coupled with the narrowness of the line (~15-25 km s-1), makes it extremely easy to detect PNe in external galaxies using ...
Barlow, MJ
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way
The Astrophysical JournalUsing Gaia Data Release 3 astrometry and spectroscopy, we study two new substructures in the orbit–metallicity space of the inner Milky Way: Shakti and Shiva.
Khyati Malhan, Hans-Walter Rix
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A Novel Approach to Identifying Substructures through Analysis of Metallicity Distribution Functions
The Astrophysical JournalWe present a new method for identifying Galactic halo substructures accreted from dwarf galaxies by combining metallicity distribution functions (MDFs) with orbital parameters.
Young Kwang Kim +2 more
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A Bayesian Approach to the Vertical Structure of the Disk of the Milky Way
The Open Journal of Astrophysics, 2020 This work investigates the vertical profile of the stars in the disk of the Milky Way. The models investigated are of the form sech2/n(nz/(2H)) where, setting α = 2/n, the three functions of the sequence α= 0, 1, 2 correspond to exponential, sech, and ...
Phillip S. Dobbie , Stephen J. Warren
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The origin of the Milky Way globular clusters
, 2019 We present a cosmological zoom-in simulation of a Milky Way-like galaxy used to explore the formation and evolution of star clusters. We investigate in particular the origin of the bimodality observed in the colour and metallicity of globular clusters ...
Renaud, Florent +2 more
core +2 more sources
SynthPop: A New Framework for Synthetic Milky Way Population Generation
The Astronomical JournalWe present SynthPop , a new open source, modular population synthesis Galactic modeling software to simulate catalogs of Milky Way stars along any sightline outward from the Sun. Motivated by a lack of flexibility in existing Galactic models, SynthPop is
Jonas Klüter +8 more
doaj +1 more source