Results 61 to 70 of about 126,794,803 (294)

He Awa Whiria: The Tidal Streams of Interstellar Objects

The Astrophysical Journal
Upcoming surveys are likely to discover a new sample of interstellar objects (ISOs) within the solar system, but questions remain about the origin and distribution of this population within the Galaxy.
John C. Forbes, Michele T. Bannister, Chris Lintott, Angus Forrest, Simon Portegies Zwart, Rosemary C. Dorsey, Leah Albrow, Matthew J. Hopkins   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Milky Way Is a Less Massive Galaxy—New Estimates of the Milky Way’s Local and Global Stellar Masses

The Astrophysical Journal Letters
Stellar mass is the most fundamental property of a galaxy. While it has been robustly measured for millions of external galaxies, it remains poorly constrained for the Milky Way because of the strong selection effect from our inside perspective.
Jianhui Lian, Tao Wang, Qikang Feng, Yang Huang, Helong Guo   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Gaussian Process Methods for Very Large Astrometric Data Sets

The Astrophysical Journal
We present a novel nonparametric method for inferring smooth models of the mean velocity field and velocity dispersion tensor of the Milky Way from astrometric data.
Timothy Hapitas, Lawrence M. Widrow, Thavisha E. Dharmawardena, Daniel Foreman-Mackey   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

On the Formation of Planets in the Milky Way’s Thick Disk

The Astrophysical Journal
Exoplanet demographic surveys have revealed that close-in (≲1 au) small planets orbiting stars in the Milky Way’s thick disk are ∼50% less abundant than those orbiting stars in the Galactic thin disk.
Tim Hallatt, Eve J. Lee
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way

The Astrophysical Journal
Using Gaia Data Release 3 astrometry and spectroscopy, we study two new substructures in the orbit–metallicity space of the inner Milky Way: Shakti and Shiva.
Khyati Malhan, Hans-Walter Rix
doaj   +1 more source