Results 161 to 170 of about 3,556 (301)

Discovery and Spectroscopic Confirmation of Aquarius III: A Low-mass Milky Way Satellite Galaxy

The Astrophysical Journal
We present the discovery of Aquarius III, an ultra-faint Milky Way satellite galaxy identified in the second data release of the DECam Local Volume Exploration survey.
W. Cerny, A. Chiti, M. Geha, B. Mutlu-Pakdil, A. Drlica-Wagner, C. Y. Tan, M. Adamów, A. B. Pace, J. D. Simon, D. J. Sand, A. P. Ji, T. S. Li, A. K. Vivas, E. F. Bell, J. L. Carlin, J. A. Carballo-Bello, A. Chaturvedi, Y. Choi, A. Doliva-Dolinsky, O. Y. Gnedin, G. Limberg, C. E. Martínez-Vázquez, S. Mau, G. E. Medina, M. Navabi, N. E. D. Noël, V. M. Placco, A. H. Riley, I. U. Roederer, G. S. Stringfellow, C. R. Bom, P. S. Ferguson, D. J. James, D. Martínez-Delgado, P. Massana, D. L. Nidever, J. D. Sakowska, L. Santana-Silva, N. F. Sherman, E. J. Tollerud, DELVE Collaboration   +40 more
doaj   +1 more source

Habitability near the Center of Active, Milky Way-like Galaxies

, 2019
https://rdc.reed.edu/v1/resources/f7da1e8c-e47d-4ead-9f47-00c9d580794b/thumb/128.jpgAtmospheric loss of a planet due to an active galactic nucleus (AGN) is calculatedusing numerical integration techniques.
Schlack, Trevor
core  

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

The Effects of Linear Matter Power Spectrum Enhancement on Dark Matter Substructure

The Astrophysical Journal
We present cosmological dark matter (DM)–only zoom-in simulations of a Milky Way analog originating from enhanced linear matter power spectra P ( k ) relative to the standard cold, collisionless DM (CDM) cosmology.
Ethan O. Nadler, Vera Gluscevic, Andrew Benson   +2 more
doaj   +1 more source

Revealing the Heart of the Galaxy: The Milky Way and its Black Hole

, 2014
1. Introduction: the luminous pathway; 2. The discovery of the Milky Way Galaxy; 3. The new physics; 4. Parting the veil with radio astronomy; 5. The violent Universe; 6. New windows on the Galactic Center; 7.
Sanders, Robert H.
core  

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Cosmic Rays Masquerading as Hot CGM Gas: An Inverse-Compton Origin for Diffuse X-ray Emission in the Circumgalactic Medium

The Open Journal of Astrophysics
Observations from _ROSAT_ and _eROSITA_ have argued that Milky Way (MW), Andromeda, and lower-mass galaxies exhibit extended soft X-ray ($1\,$keV) diffuse halos out to radii $R\gtrsim 100\,$kpc in the circumgalactic medium (CGM).
Philip F. Hopkins, Eliot Quataert, Sam B. Ponnada, Emily Silich   +3 more
doaj   +1 more source

The Centres of M83 and the Milky Way: opposite extremes of a common star formation cycle

This dataset contains the supporting data from The Centres of M83 and the Milky Way: opposite extremes of a common star formation cycle, Callanan et al. 2021, MNRAS.
Callanan, Daniel
core   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source