Results 141 to 150 of about 3,556 (301)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Measuring the mass of the Milky Way using observations of radio waves emitted by neutral hydrogen

, 2021
In this experiment we studied the rotation of the spiral arms of the Milky Way and estimated its total mass by observing radio waves emitted from neutral hydrogen within the spiral arms. The spin-flip transition in a hydrogen atom results in the emission
Nix, Brianna, Guerin, Spencer, Nedvidek, Brendan, Sherwood, Dana, Chen, Angela   +4 more
core  

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Dark matter debris flows in the Milky Way

, 2012
We show that subhalos falling into the Milky Way create a flow of tidally-stripped debris particles near the Galactic center with characteristic speed behavior, but no spatial features. Using the Via Lactea-II N-body simulation, we study the unvirialized
Lisanti, Mariangela, Spergel, David N.
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

The Three-mm Ultimate Mopra Milky Way Survey. III. Data Release 6, An Atlas of Physical Conditions, Global Mass Conversion Laws, and 3D Physical Architecture of the Molecular Interstellar Medium in the Fourth Quadrant

The Astrophysical Journal Supplement Series
Abstract We present Data Release 6 of ThrUMMS, consisting of complete data cubes and various moments of line emission (12CO, 13CO, C18O) from molecular clouds, across 60° × 2° of the Fourth Quadrant (4Q) of the Milky Way at a resolution of 72″ in (l, b) and 0.09 km s−1 in V LSR.
Peter J. Barnes, Dylan G. H. Barnes, Audra K. Hernández, Sebastian Lopez, Erik Muller   +4 more
openaire   +1 more source

The characterization of the gamma-ray signal from the central Milky Way: A case for annihilating dark matter

, 2018
Past studies have identified a spatially extended excess of ~1-3 GeV gamma rays from the region surrounding the Galactic Center, consistent with the emission expected from annihilating dark matter. We revisit and scrutinize this signal with the intention
Linden, Tim, Rodd, Nicholas Llewellyn, Portillo, Stephen K.N., Finkbeiner, Douglas P., Daylan, Tansu, Slatyer, Tracy Robyn, Hooper, Dan   +6 more
core   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Molecular Clouds Resolved at the Onset of Cosmic Noon

The Astrophysical Journal Letters
We present the discovery of seven molecular clouds in the radio galaxy B2 0902+34 at redshift z = 3.4. These clouds are detected as CO(0–1) absorption features against the bright radio continuum and spectrally resolved using the Karl G. Jansky Very Large
Bjorn H. C. Emonts, Matthew D. Lehnert, Mingyu Li, Azia Robinson, Stephen J. Curran, Montserrat Villar-Martín, Chris L. Carilli, Raffaella Morganti, Ilsang Yoon, Pierre Guillard, George K. Miley, Reinout J. van Weeren, Zheng Cai   +12 more
doaj   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source