Results 131 to 140 of about 3,556 (301)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

Fundamental physics opportunities with the next-generation Event Horizon Telescope

Living Reviews in Relativity
The Event Horizon Telescope (EHT) Collaboration recently published the first images of the supermassive black holes in the cores of the Messier 87 and Milky Way galaxies.
Dimitry Ayzenberg, Lindy Blackburn, Richard Brito, Silke Britzen, Avery E. Broderick, Raúl Carballo-Rubio, Vitor Cardoso, Andrew Chael, Koushik Chatterjee, Yifan Chen, Pedro V. P. Cunha, Hooman Davoudiasl, Peter B. Denton, Sheperd S. Doeleman, Astrid Eichhorn, Marshall Eubanks, Yun Fang, Arianna Foschi, Christian M. Fromm, Peter Galison, Sushant G. Ghosh, Roman Gold, Leonid I. Gurvits, Shahar Hadar, Aaron Held, Janice Houston, Yichao Hu, Michael D. Johnson, Prashant Kocherlakota, Priyamvada Natarajan, Héctor Olivares, Daniel Palumbo, Dominic W. Pesce, Surjeet Rajendran, Rittick Roy, Saurabh, Lijing Shao, Shammi Tahura, Aditya Tamar, Paul Tiede, Frédéric H. Vincent, Luca Visinelli, Zhiren Wang, Maciek Wielgus, Xiao Xue, Kadri Yakut, Huan Yang, Ziri Younsi   +47 more
doaj   +1 more source

Teasing Out the True Milky Way

Presentation Date: Tuesday, September 10, 2019. Location: Institute for Advanced Study, Princeton, NJ. Abstract: It has been nearly 100 years since the "Great Debate," where Heber Curtis correctly argued that Thomas Wright's 1750 ideas about our ...
Goodman, Alyssa
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Understanding the Milky Way with Stars

"How do galaxies form?" is one of the most important questions in modern astrophysics. Hierarchical growth, the most plausible theory behind galaxy formation, suggests that galaxies, including the Milky Way, assemble through the accretion of smaller ...
Ou, Xiaowei
core  

Around The Way: Testing $\Lambda$CDM with Milky Way Stellar Stream Constraints

, 2018
International audienceRecent analyses of the Pal 5 and GD-1 tidal streams suggest that the inner dark matter halo of the Milky Way is close to spherical, in tension with predictions from collisionless N-body simulations of cosmological structure ...
Madau, Piero, Biwei Dai, Dai, Biwei, Robertson, Brant E., Piero Madau, Brant E. Robertson   +5 more
core   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Towards a Measurement of the Primordial Helium Isotope Ratio

The Astrophysical Journal
We report the discovery of two metastable neutral helium (He I *) absorbers in the Milky Way, and use the upgraded CRyogenic InfraRed Echelle Spectrograph (or CRIRES) on the Very Large Telescope to determine the helium isotope ratio, ^3 He/ ^4 He, along ...
Ryan J. Cooke, James W. Johnson, Pasquier Noterdaeme, Max Pettini, Louise Welsh, Aldric Wong, Céline Péroux   +6 more
doaj   +1 more source

The magnetic field in the Milky Way filamentary bone G47 [PDF]

Funding: R.J.S. acknowledges funding from an STFC ERF (grant ST/N00485X/1).Star formation primarily occurs in filaments where magnetic fields are expected to be dynamically important.
Goodman, Alyssa, Pillai, Thushara, Coude, Simon, Smith, Howard A., Kusune, Takayoshi, Zuckerman, Leah, Hogge, Taylor, Looney, Leslie W., Guzman, Andres, Sanhueza, Patricio, Encalada, Frankie, Smith, Rowan, Stephens, Ian W., Myers, Philip C., Sugitani, Koji, Novak, Giles, Santos, Fabio P., Zucker, Catherine, Sadavoy, Sarah, Soam, Archana, Andersson, B-G, Li, Zhi-Yun, Jackson, James M., Battersby, Cara   +23 more
core   +1 more source