Results 41 to 50 of about 134,171,610 (311)

COMPARATIVE EVALUATION OF THE EFFICACY AND SAFETY OF VALPROIC ACID DERIVATIVES

Эпилепсия и пароксизмальные состояния, 2016
: this article discusses the comparative efficacy and safety of valproic acid derivatives (various salts), and the original of generic drugs based on it, are the literature data and the results of our experimental and clinical studies on the ...
O. L. Badalyan, S. G. Burd, A. A. Savenkov, G. G. Avakyan, E. V. Yutskova, G. N. Avakyan   +5 more
doaj  

Comparative efficacy and safety of generic (Bergolak) vs. brand cabergoline in the treatment of patients with prolactin-secreting tumors

Ожирение и метаболизм, 2015
Objective: To evaluate the effectiveness and safety of cabergoline drug Bergolak («Veropharm», Russia) in the treatment of patients with prolactin-secreting tumors.Materials and methods: The study included 14 patients (14 women, mean age 46±12) diagnosed
Galina Afanas'evna Melnichenko, Larisa Konstantinovna Dzeranova, Ekaterina Aleksandrovna Pigarova, Svetlana Yur'evna Vorotnikova   +3 more
doaj   +1 more source

The role of drugs in the origin of AIDS

Biomedicine & Pharmacotherapy, 1992
It is proposed that the new American and European AIDS epidemics are caused by recreational and anti-HIV drugs rather than by human immunodeficiency virus (HIV). Chronologically, the AIDS epidemic in the 1980s followed a massive escalation in the consumption of recreational drugs that started in the 1960s and 70s.
openaire   +2 more sources

Drug use among secondary school students, New South Wales, 1986

, 2019
This survey has a number of objectives: to monitor the nature and extent of alcohol and other drug use; to provide data from which the need for social policy and educational initiatives could be determined; and to provide background data to facilitate ...
NSW Drug and Alcohol Authority
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Targeting GRP75 with a Chlorpromazine Derivative Inhibits Endometrial Cancer Progression Through GRP75–IP3R‐Ca2+‐AMPK Axis

Advanced Science
Tumors often overexpress glucose‐regulated proteins, and agents that interfere with the production or activity of these proteins may represent novel cancer treatments.
Qi Wang, Lijuan Li, Xiaoyan Gao, Chunxue Zhang, Chen Xu, Lingyi Song, Jian Li, Xiao Sun, Fei Mao, Yudong Wang   +9 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Original drugs approved by the Food and Drug Administration (Center for Drug Evaluation and Research) in 2024

Фармация и фармакология (Пятигорск)
The U.S. Food and Drug Administration (FDA), in particular the Center for Drug Evaluation and Research (CDER), plays a key role in ensuring the safety, efficacy, and innovation of medicines entering the U.S. market, and then the world.
D. V. Kurkin, N. A. Osadchenko, A. R. Makarova, D. A. Galkina, D. A. Bakulin, O. V. Shatalova, A. V. Strygin, V. I. Petrov, O. V. Marincheva, Yu. V. Gorbunova, Yu. A. Kolosov, A. V. Zaborovsky, D. V. Yunina, K. N. Koryanova, E. I. Morkovin, M. A. Dzhavakhyan, V. I. Zvereva, R. V. Drai, I. E. Makarenko, A. S. Shuvaeva   +19 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An Update on CFTR Drug Discovery: Opportunities and Challenges

Biomolecules, 2022
The Biomolecules Special issue on “An Update on CFTR Drug Discovery: Opportunities and Challenges” includes three original research articles and a webinar session focusing on some recent findings concerning CFTR drug discovery [...]
Pasqualina D’Ursi, Paola Fossa
doaj   +1 more source