Results 61 to 70 of about 134,171,610 (311)

Sudden Death of Cardiac Origin and Psychotropic Drugs [PDF]

Frontiers in Pharmacology, 2012
Mortality rate is high in psychiatric patients versus general population. An important cause of this increased mortality is sudden cardiac death (SCD) as a major side-effect of psychotropic drugs. These SCDs generally result from arrhythmias occurring when the posology is high and may attain a toxic threshold but also at dosages within therapeutic ...
Timour, Quadiri, Frassati, Dominique, Descotes, Jacques, Chevalier, Philippe, Christé, Georges, Chahine, Mohamed   +5 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Original drug or generic?

, 2010
Перед врачом в повседневной практике возникает непростой вопрос выбора препарата для лечения: оригинальный препарат или генерик? Результаты исследования, проведены в лаборатории «ACC GmbH Analytical Concepts» (Германия), свидетельствуют о том, что ...
Гайдукова, С.Н., Карнабеда, О.А.   +1 more
core   +1 more source

Ksenikal v kompleksnom lechenii patsientovs izbytochnoy massoy tela i ozhireniem

Ожирение и метаболизм, 2010
This article shows a significant efficacy and safety data of original drug Xenical in complex treatment of overweight and obesity patients. It is emphasized that this data describe properties of original Xenical, but not generics.

doaj   +1 more source

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery.

, 2020
Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Beloqui Garcia, Ana, Memvanga, Patrick, Aristote B. Buya, Véronique Préat, Buya, Aristote Banzenga, Ana Beloqui, Préat, Véronique, Patrick B. Memvanga   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Accurate prediction of drug-protein interactions by maintaining the original topological relationships among embeddings

BMC Biology
Background Learning-based methods have recently demonstrated strong potential in predicting drug-protein interactions (DPIs). However, existing approaches often fail to achieve accurate predictions on real-world imbalanced datasets while maintaining high
Yanfei Li, Xiran Chen, Shuqin Wang, Jinmao Wei   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

OPEN-LABEL RANDOMIZED CROSS-SECTIONAL STUDY OF CLINICAL EQUIVALENCE OF GENERIC AND ORIGINAL VALSARTAN IN PATIENTS WITH ARTERIAL HYPERTENSION

Кардиоваскулярная терапия и профилактика, 2015
To compare antihypertensive effectiveness and changes of lipid and carbohydrate metabolism profiles, erectile function and life quality in patients with arterial hypertension (AH) while being treated by generic valsartan (Tantordio) comparing to the ...
V. B. Mychka, A. L. Vertkin, S. N. Tolstov, Yu. V. Prokhorova, E. I. Uzuyeva, М. А. Khamurzova   +5 more
doaj   +1 more source

Brief strategic family therapy for adolescent drug abuse. [PDF]

, 2003
To ensure that treatment providers apply the most current scientifically supported approaches to their patients, NIDA has supported the development of the "Therapy Manuals for Drug Addiction" series.

core