Results 51 to 60 of about 1,506,259 (261)

Sudden Death of Cardiac Origin and Psychotropic Drugs [PDF]

Frontiers in Pharmacology, 2012
Mortality rate is high in psychiatric patients versus general population. An important cause of this increased mortality is sudden cardiac death (SCD) as a major side-effect of psychotropic drugs. These SCDs generally result from arrhythmias occurring when the posology is high and may attain a toxic threshold but also at dosages within therapeutic ...
Timour, Quadiri, Frassati, Dominique, Descotes, Jacques, Chevalier, Philippe, Christé, Georges, Chahine, Mohamed   +5 more
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Accurate prediction of drug-protein interactions by maintaining the original topological relationships among embeddings

BMC Biology
Background Learning-based methods have recently demonstrated strong potential in predicting drug-protein interactions (DPIs). However, existing approaches often fail to achieve accurate predictions on real-world imbalanced datasets while maintaining high
Yanfei Li, Xiran Chen, Shuqin Wang, Jinmao Wei   +3 more
doaj   +1 more source

OPEN-LABEL RANDOMIZED CROSS-SECTIONAL STUDY OF CLINICAL EQUIVALENCE OF GENERIC AND ORIGINAL VALSARTAN IN PATIENTS WITH ARTERIAL HYPERTENSION

Кардиоваскулярная терапия и профилактика, 2015
To compare antihypertensive effectiveness and changes of lipid and carbohydrate metabolism profiles, erectile function and life quality in patients with arterial hypertension (AH) while being treated by generic valsartan (Tantordio) comparing to the ...
V. B. Mychka, A. L. Vertkin, S. N. Tolstov, Yu. V. Prokhorova, E. I. Uzuyeva, М. А. Khamurzova   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The role of the micronized purified flavonoid fraction drug in lower extremities chronic vein diseases treatment

Амбулаторная хирургия
Chronic venous diseases of the lower extremities, including varicose veins, are one of the most common pathologies in modern society, affecting up to 73% of women and up to 56% of men.
E. A. Shcheglov, N. N. Alontseva
doaj   +1 more source

COMPARISON OF THE ORIGINAL (PLAVIx) AND GENERIC (CLAPITAx) CLOPIDOGREL ON PLATELET  AGGREGATION: ObSERVATIONAL STUDY

Российский кардиологический журнал, 2018
Aim. To compare antiplatelet activeness of the original clopidogrel and its generic, and to evaluate the routine practice of antiplatelet drugs intake by clinically stable patients aiming prevention of atherothrombosis.Material and methods.
A. S. Skotnikov, Zh. M. Sizova, A. N. Baglikov, O. G. Rozhnova, N. I. Novitsky   +4 more
doaj   +1 more source