Results 51 to 60 of about 1,564,441 (330)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Exclusion Problems and the Cardinality of Logical Space [PDF]
, 2016 Wittgenstein’s atomist picture, as embodied in his Tractatus, is initially very appealing. However, it faces the famous colour-exclusion problem. In this paper, I shall explain when the atomist picture can be defended (in principle) in the face of that ...
Button, Tim
core +3 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The Principle of Autonomy in Kant's Moral Theory: Its Rise and Fall [PDF]
, 2018 In this essay, “The Principle of Autonomy in Kant’s Moral Theory: Its Rise and Fall,” Pauline Kleingeld notes that Kant’s Principle of Autonomy, which played a central role in both the Groundwork for the Metaphysics of Morals and the Critique of ...
Kleingeld, Pauline
core
Non-existence of a Hohenberg-Kohn Variational Principle in Total Current Density Functional Theory
, 2014 For a many-electron system, whether the particle density $\rho(\mathbf{r})$ and the total current density $\mathbf{j}(\mathbf{r})$ are sufficient to determine the one-body potential $V(\mathbf{r})$ and vector potential $\mathbf{A}(\mathbf{r})$, is still ...
Benedicks, Michael, Laestadius, Andre
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
REGULARIZATION OF PONTRYAGIN MAXIMUM PRINCIPLE IN OPTIMAL CONTROL OF DISTRIBUTED SYSTEMS
Ural Mathematical Journal, 2016 This article is devoted to studying dual regularization method applied to parametric convex optimal control problem of controlled third boundary–value problem for parabolic equation with boundary control and with equality and inequality pointwise state ...
Mikhail I. Sumin
doaj +1 more source
Journal of Modern Philosophy, 2022 The distinction between voluntarism and intellectualism has recently been criticized for inaccurately characterising early modern theories of divine freedom.
Lukas Wolf
doaj +1 more source
The law of becoming and the shackles of sufficient reason in Quentin Meillassoux [PDF]
, 2014 Examining the concept of ‘hyper-chaos’ - a time beyond time, not of perpetual becoming, but of lawless creation and destruction, premised upon an abandonment of the principle of sufficient reason - as described in the work of French philosopher Quentin ...
Sutherland, Thomas
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