Results 61 to 70 of about 177,037,955 (220)

A Hermeneutic Phenomenology: The Death of the Other Understood as Event

Journal of Applied Hermeneutics, 2017
This is a phenomenological description of what is happening when we experience the death of an other that interprets surviving or living on after such death by employing the term event.
Harris B. Bechtol
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

On the Principle of Sufficient Reason [PDF]

, 2006
The aim of this paper is to defend the Principle of Sufficient Reason (PSR). I analyse various versions of this principle (and their structure) and various ways of justifying it.
Wojtysiak, Jacek
core  

On the Fourfold Root of the Principle of Sufficient Reason and on the Will in Nature [PDF]

, 1891
On the Fourfold Root of the Principle of Sufficient Reason is an elaboration on the classical Principle of Sufficient Reason written by German philosopher Arthur Schopenhauer as his doctoral dissertation in 1813.
Schopenhauer, Arthur, Hillebrand, Karl
core   +1 more source

Crusius and the Pre-critical Kant on the Principle of Determining Reason and the Ontological Argument

Daimon
In his version of the so-called Thomistic objection against the ontological argument, Kant follows Crusius in replacing the term “sufficient” for “determining” in the formulation ‛principle of reason’ as an attempt to distinguish logical possibility ...
Ignacio Garay
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A fundamentação das ciências compreensivas: a posição de Dilthey reconstruída a partir de Leibniz, Wolff e Kant [PDF]

Princípios, 2007
Dilthey’s work fills a fundamental role in contemporary philosophy insofar as Dilthey distinguishes two spheres through which we have access to all of reality: objective experience (die Erfahrung) and lived experience (das Erlebnis).
Marcos César Seneda
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Few Words about Spinoza, a Philosopher of Few or, Perhaps, No Words

Journal of Spinoza Studies, 2022
Michael Della Rocca
doaj   +1 more source

Reinterpreting Schopenhauer’s Fourfold Root: Causality, Immanence, and the Limits of Metaphysical Explanation

Philosophies
Background: Arthur Schopenhauer’s On the Fourfold Root of the Principle of Sufficient Reason (in its revised 1847 edition) has been variously interpreted as an epistemological prelude to his metaphysics of will, as a continuation of Kantian ...
Jan Kerkmann
doaj   +1 more source