Results 71 to 80 of about 1,564,441 (330)
Paradoxes of causal loops in spacetime [PDF]
, 2013 There is, among some scientists and philosophers, the idea that any theory that would allow the time travel would introduce causal issues. These types of temporal paradoxes can be avoided by the Novikov self-consistency principle or by a variation in the
Du, Chunyun +3 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Hume's Correlationism: On Meillassoux, Necessity and Belief
Journal of French and Francophone Philosophy, 2013 The article argues that Meillassoux's 'After Finitude' underestimates the nature and profundity of Hume's sceptical challenge; it neglects the fact that Hume's scepticism concerns final causes (and agrees fundamentally with Bacon and Descartes in this ...
Paul O'Mahoney
doaj +1 more source
Metaphysical Foundationalism and the Principle of Sufficient Reason
Dialogue, 2022 AbstractThere is a ubiquitous claim in the grounding literature that metaphysical foundationalism violates the principle of sufficient reason (PSR) in virtue of positing a level of ungrounded facts. I argue that foundationalists can accept the PSR if they are willing to replace fundamentality as independence with completeness and deny that ground is a ...
openaire +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A Hermeneutic Phenomenology: The Death of the Other Understood as Event
Journal of Applied Hermeneutics, 2017 This is a phenomenological description of what is happening when we experience the death of an other that interprets surviving or living on after such death by employing the term event.
Harris B. Bechtol
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
How Did Leibniz’s God Create the World?
Journal of Modern PhilosophyI show that Leibniz’s account of divine concurrence is constrained in a surprising way by his commitment to the Principle of Sufficient Reason, where a sufficient reason for the existence of an entity or a state of affairs is understood to be the ...
Fatema Amijee
doaj +2 more sources
A parassubordinação como forma de discriminação [PDF]
, 2017 This article aims to study parasubordination (quasi-subordination) in labour law. Firstly we present the concept of parasubordination in italian law and we discuss legislative modifications developed in this matter lately.
Vasconcelos Porto, Lorena
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