Results 81 to 90 of about 177,037,955 (220)

Comparison of the views of the Mu\\\'tazilite and Leibniz on Divine Justice [PDF]

open access: yesComparative Theology, 2013
Mu'tazilite was a group of Muslim theologians, who attributed themselves to the just people; Reference of justice among them was that God calculates human actions. They believed each person is responsible for his actions. This was the problem that caused
Amrolah Moein
doaj   +1 more source

Leibniz on the PSR as a Regulative Principle of Rational Inquiry

open access: yesJournal of Modern Philosophy
One of Leibniz’s fundamental philosophical commitments is the principle of sufficient reason (PSR). Yet Leibniz’s precise understanding of this principle is elusive.
Juan Garcia Torres
doaj   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Quentin Meillassoux and the Rehabilitation of the Principle of Sufficient Reason [PDF]

open access: green, 2017
Quentin Meillassoux has sparked new debates within contemporary philosophy. One of his suggestions is that the principle of sufficient reason leads to an infinite regress, unless the ontological argument uncovers a reason that accounts for everything ...
Martín Orensanz
openalex   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Sculpting Character: Aristotle's Voluntary as Affectability

open access: yesLabyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2016
I argue that the two criteria traditionally identified as jointly sufficient for voluntary behavior according to Aristotle require qualification. Without such qualification, they admit troubling exceptions (i.e., they are not sufficient). Through minding
Audrey L. Anton
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

open access: yesFEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen   +5 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

Quentin Meillassoux’s Speculative Materialism as a Manifestation of the Rationality of Non-one

open access: yesНаукові записки НаУКМА: Філософія та релігієзнавство, 2019
This article has a twofold aim. First, it attempts to reconstruct and critically analyze arguments provided by Quentin Meillassoux, a contemporary French philosopher, for his central philosophical thesis: only contingency is necessary.
Vasyl Korchevnyi
doaj   +1 more source

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