Results 81 to 90 of about 1,564,441 (330)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Crusius and the Pre-critical Kant on the Principle of Determining Reason and the Ontological Argument

open access: yesDaimon
In his version of the so-called Thomistic objection against the ontological argument, Kant follows Crusius in replacing the term “sufficient” for “determining” in the formulation ‛principle of reason’ as an attempt to distinguish logical possibility ...
Ignacio Garay
doaj   +1 more source

A fundamentação das ciências compreensivas: a posição de Dilthey reconstruída a partir de Leibniz, Wolff e Kant [PDF]

open access: yesPrincípios, 2007
Dilthey’s work fills a fundamental role in contemporary philosophy insofar as Dilthey distinguishes two spheres through which we have access to all of reality: objective experience (die Erfahrung) and lived experience (das Erlebnis).
Marcos César Seneda
doaj  

Merely possible explanation [PDF]

open access: yes, 2017
Graham Oppy has argued that possible explanation entails explanation in order to object to Richard Gale and Alexander Pruss's new cosmological argument that it does not improve upon familiar cosmological arguments.
GUIGON, GHISLAIN
core  

Limitations and the World Beyond

open access: yesLogic, Epistemology, and the Unity of Science, 2017
: This paper surveys our inescapable limits as cognitive agents with regard to a full world of fact: the well-known metamathematical limits of axiomatic systems, limitations of explanation that doom a principle of sufficient reason, limitations of ...
P. Grim, N. Rescher
semanticscholar   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

A Few Words about Spinoza, a Philosopher of Few or, Perhaps, No Words

open access: yesJournal of Spinoza Studies, 2022
Michael Della Rocca
doaj   +1 more source

The Principle of Sufficient Reason in Spinoza [PDF]

open access: yes, 2013
This chapter investigates Spinoza’s commitment to the Principle of Sufficient Reason (the PSR) and its role in his system. What sorts of things does Spinoza think require a cause or explanation? What counts, for him, as a cause or explanation? The PSR is often associated with doctrines such as necessitarianism, the Principle of the Identity of ...
openaire   +1 more source

Every man has his price: Kant's argument for universal radical evil [PDF]

open access: yes, 2022
Kant famously claims that we have all freely chosen evil. This paper offers a novel account of the much-debated justification for this claim. I reconstruct Kant’s argument from his affirmation that we all have a price – we can all succumb to temptation ...
Indregard, Jonas Jervell
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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