Results 51 to 60 of about 507,734 (290)
Advanced Science, EarlyView.This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo +9 more
wiley +1 more source
Griffin on the Traditional Theological Approaches to the Problem of Evil [PDF]
پژوهشنامه فلسفه دین, 2018 One of the most important issues in theology and philosophy of religion is the problem of evil and its relation to God and his omnipotence and omnibenevolence.
Haajar Darbandi Darian +2 more
doaj +1 more source
, 2017 Skeptical theism is a family of responses to the evidential problem of evil. What unifies this family is two general claims. First, that even if God were to exist, we shouldn’t expect to see God’s reasons for permitting the suffering we observe.
Perrine, Timothy, Wykstra, Stephen
core +1 more source
Advanced Science, EarlyView.ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang +8 more
wiley +1 more source
Actualizing Unique Type and Token Values as a Solution to the Problem of Evil
Religions, 2017 Concerning the problem of evil, I suggest that God's goodness and omnipotence causes God to want to actualize many different values and things, not solely angels in heaven, but also type unique values like independence, self-formation, creativity, and ...
Atle Ottesen Søvik
doaj +1 more source
Brian Davies on the Problem of Evil: A Critical Study [PDF]
پژوهشنامه فلسفه دین, 2018 Brian Davies is one of the contemporary philosophers of religion who has given serious critiques of the dominant approach in contemporary philosophy of religion.
Zolfaghar Naseri, Mansour Nasiri
doaj +1 more source
On the Metaphysical Necessity of Suffering from Natural Evil [PDF]
, 2013 Why does God permit suffering in the world? If God is wholly good, omnipotent, and omniscient, why would He not intervene to prevent us from suffering?
Sullivan, Ryan Edward
core +1 more source
Advanced Science, EarlyView.ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao +12 more
wiley +1 more source
Explaining the Origin of Negative Poisson's Ratio in Amorphous Networks With Machine Learning
Advanced Intelligent Discovery, EarlyView.This review summarizes how machine learning (ML) breaks the “vicious cycle” in designing auxetic amorphous networks. By transitioning from traditional “black‐box” optimization to an interpretable “AI‐Physics” closed‐loop paradigm, ML is shown to not only discover highly optimized structures—such as all‐convex polygon networks—but also unveil hidden ...
Shengyu Lu, Xiangying Shen
wiley +1 more source