Results 171 to 180 of about 1,039,047 (309)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Sociotechnical analysis of qualitative data using a large language model-assisted framework with performance compared to a human-only coded reference standard. [PDF]

JAMIA Open
Butler JM, Jones M, Balbin C, Taber P, Del Fiol G, Dalrymple R, Kawamoto K.   +6 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Theme-based multi-class object recognition and segmentation

, 2010
In this paper, we propose a new theme-based CRF model and investigate its performance on class based pixel-wise segmentation of images. By including the theme of an image, we also propose a new texture-environment potential to represent texture ...
Wu SL(吴士林), Geng JJ(耿佳佳), Zhu F(朱枫)   +2 more
core  

Nurses' Engagement in Healthcare Policy-Making: A Pragmatic Utility-Based Scoping Review. [PDF]

Int Nurs Rev
Albanesi B, Casciaro R, Casabona E, Conti A, Alite-Cerezuela P, Cooke S, Kane R, Karavani N, Velonaki VS, Vizcaya F, Zabalegui A, Sammut R, Clari M.   +12 more
europepmc   +1 more source

Variations on a Theme [PDF]

British Journal of Ophthalmology, 1938
openaire   +2 more sources

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Theme-Based Comprehensive Evaluation in New Product Development Using Fuzzy Hierarchical Criteria Group Decision-Making Method

, 2011
One of the features of the digital ecosystem is the integration of human cognition and socio-economic themes into the process of new product development (NPD).
Guangquan Zhang (6938171), Ludovic Koehl (20222460), Yijun Zhu (2975739), Jie Lu (139953), Jun Ma (20121735), Xianyi Zeng (19194349)   +5 more
core  

Aging Like Milk or Fine Wine: Content Analysis of Reactions to One's Future Self on TikTok. [PDF]

JMIR Aging
Ng R, Indran N.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source