Results 41 to 50 of about 138,093 (211)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Using the theoretical domains framework to determine the barriers and facilitators to medication adherence in Parkinson's disease

Exploratory Research in Clinical and Social Pharmacy, 2023
Background: Patient medication adherence in Parkinson's Disease (PD) is often suboptimal. This may lead to poor symptom management, greater disease burden, decreased quality of life and increased healthcare costs.
J.C. Smith, C.H. Seage, E. Lane, D.H. James   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Initial validation of a self-report questionnaire based on the Theoretical Domains Framework: determinants of clinician adoption of a novel colorectal cancer screening strategy

Implementation Science Communications, 2021
Background Colorectal cancer (CRC) screening for average risk adults age 45 and older continues to be underutilized in the USA. One factor consistently associated with CRC screening completion is clinician recommendation.
Xuan Zhu, Minji K. Lee, Emily Weiser, Joan M. Griffin, Paul J. Limburg, Lila J. Finney Rutten   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Development and application progress on theoretical domains framework

Huli yanjiu, 2016
More and more research suggests that the research of occupational behavior of medical staff and the establishment of clinical intervention should be based on scientific theory.But the existing theories of psychology were various,and many theories ...
花文哲, 刘珊珊, 朱大乔
doaj  

Internists’ deprescribing behavior for proton pump inhibitor therapy: a qualitative study based on the theoretical domains framework internists’ deprescribing behavior for PPI therapy

BMC Health Services Research
Background Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. However, they are often used inappropriately and may cause adverse effects in long-term use.
Beyza Nur Ataoğlu, Betul Okuyan, Rabia Yaren Şahin, Beril Koçak, Ayberk Denizli, Asiye Sena Anli, Pınar Ay   +6 more
doaj   +1 more source

Barriers and facilitators for leading nursing homes through the COVID‐19 pandemic: A focus group study in Norway

Nursing Open, 2023
Background During the COVID‐19 pandemic, nursing home leaders implemented infection control to protect residents and staff. Aim To understand the barriers and facilitators for leading nursing homes through the COVID‐19 pandemic.
Gro Beate Samdal, Lise‐Merete Alpers, Ragnhild Johanne Tveit Sekse, Sigrunn Drageset, Hilde Smith‐Strøm, Trine Oksholm, Sidsel Ellingsen   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source