Results 71 to 80 of about 814,140 (284)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Developing theory-informed interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework [PDF]

, 2012
Background: There is little systematic operational guidance about how best to develop complex interventions to reduce the gap between practice and evidence.
Buchbinder, R., Francis, J., French, S. D., Green, S. E., McKenzie, J. E., Michie, S., O'Connor, D., Schattner, P.   +7 more
core  

Towards better understanding of gradient-based attribution methods for Deep Neural Networks [PDF]

, 2018
Understanding the flow of information in Deep Neural Networks (DNNs) is a challenging problem that has gain increasing attention over the last few years.
Ancona, Marco, Ceolini, Enea, Gross, Markus, Öztireli, Cengiz   +3 more
core   +1 more source

Opioid Prescribing After Curative-Intent Surgery: A Qualitative Study Using the Theoretical Domains Framework [PDF]

Annals of Surgical Oncology, 2018
Excessive opioid prescribing is common after curative-intent surgery, but little is known about what factors influence prescribing behaviors among surgeons. To identify targets for intervention, we performed a qualitative study of opioid prescribing after curative-intent surgery using the Theoretical Domains Framework, a well-established implementation
Jay S, Lee, Vartika, Parashar, Jacquelyn B, Miller, Samantha M, Bremmer, Joceline V, Vu, Jennifer F, Waljee, Lesly A, Dossett   +6 more
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Probabilistic Logic Programming with Beta-Distributed Random Variables

, 2018
We enable aProbLog---a probabilistic logical programming approach---to reason in presence of uncertain probabilities represented as Beta-distributed random variables. We achieve the same performance of state-of-the-art algorithms for highly specified and
Cerutti, Federico, Kaplan, Lance, Kimmig, Angelika, Sensoy, Murat   +3 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Offshore workers and health behaviour change: an exploration using the Theoretical Domains Framework

International Maritime Health, 2018
Previous research has identified the importance of promoting behaviour change within the offshore workforce. This qualitative study sought to: identify self-care behaviours perceived to require behaviour change within the offshore workforce, and explore perceived potential behavioural determinants.This study included the perspectives of both offshore ...
Gibson Smith, Kathrine, Paudyal, Vibhu, Quinn, Francis, Klein, Susan, Stewart, Derek   +4 more
openaire   +5 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Formal Framework for Speedup Learning from Problems and Solutions [PDF]

, 1996
Speedup learning seeks to improve the computational efficiency of problem solving with experience. In this paper, we develop a formal framework for learning efficient problem solving from random problems and their solutions.
Natarajan, B. K., Tadepalli, P.
core   +2 more sources