Results 51 to 60 of about 4,204,940 (272)
Understanding with Theoretical Models [PDF]
Journal of Economic Methodology, 2014 This paper discusses the epistemic import of highly abstract and simplified theoretical models using Thomas Schelling’s checkerboard model as an example. We argue that the epistemic contribution of theoretical models can be better understood in the context of a cluster of models relevant to the explanatory task at hand.
Aydinonat, N. Emrah, Ylikoski, Petri
openaire +4 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Frontiers in Neuroscience, 2018 Purpose: To present a new modified tri-exponential model for diffusion-weighted imaging (DWI) to detect the strictly diffusion-limited compartment, and to compare it with the conventional bi- and tri-exponential models.Methods: Multi-b-value diffusion ...
Qiang Zeng +5 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Brazilian Journal of Psychiatry, 1999 A compreensão da experiência dissociativa e das origens dos transtornos dissociativos é difícil devido à complexidade da questão. As contradições da classificação são decorrentes das dificuldades de se construir uma teoria da mente abrangente que ...
Paulo Jacomo Negro Junior +2 more
doaj +1 more source
THEORETICAL MODELS OF DARK ENERGY [PDF]
International Journal of Modern Physics D, 2012 Mounting observational data confirm that about 73% of the energy density consists of dark energy which is responsible for the current accelerated expansion of the Universe. We present observational evidences and dark energy projects. We then review various theoretical ideas that have been proposed to explain the origin of dark energy; they contain the ...
Yoo, Jaewon, Watanabe, Yuki
openaire +3 more sources
Theoretical Results for Sandpile Models of SOC with Multiple Topplings
, 2000 We study a directed stochastic sandpile model of Self-Organized Criticality, which exhibits recurrent, multiple topplings, putting it in a separate universality class from the exactly solved model of Dhar and Ramaswamy.
Bassler, Kevin E., Paczuski, Maya
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source