Results 71 to 80 of about 3,077,511 (309)

The canon of pure reason: Kant on the non-dependent establishment of the practical use and the unity of reason

open access: yesEthic@: an International Journal for Moral Philosophy, 2010
This paper systematically discusses Kant´s argumentation in the Canon of the Critique of pure reason on the matter of the establishment of the practical use and its outcomes for the problem of the unity of reason.
Adriano Perin
doaj   +1 more source

Is Hermann Cohen a Neo-Kantian? [PDF]

open access: yesКантовский сборник, 2015
The article focuses on overcoming the superficial approach to Neo-Kantianism: Neo-Kantianism is widely interpreted as a one-sided understanding of Kant’s works, their corruption, and, thus, a dead-end branch of the transcendental philosophy of the great ...
Belov V. N.
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

An Application Specific Informal Logic for Interest Prohibition Theory [PDF]

open access: yes, 2011
Interest prohibition theory concerns theoretical aspects of interest prohibition. We attempt to lay down some aspects of interest prohibition theory wrapped in a larger framework of informal logic.
Bergstra, J. A., Middelburg, C. A.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Groundwork for Kant’s Practical Philosophy: Construction and Meaning of the Work "Groundwork for the Metaphysics of Morals"

open access: yesAnali Hrvatskog Politološkog Društva, 2006
In the article, the author provides a systematic analysis and interpretation of Kant’s major work ‘Groundwork for the Metaphysics of Morals’. The author demonstrates that Kant viewed his programme of founding a new kind of metaphysics as a distinctive ...
Goran Gretić
doaj  

Numerical investigations of linear least squares methods for derivative estimation [PDF]

open access: yes, 2009
The results of a numerical investigation into the errors for least squares estimates of function gradients are presented. The underlying algorithm is obtained by constructing a least squares problem using a truncated Taylor expansion.
Belward, John A.   +2 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Razón practica e intelecto agente en Alfarabi

open access: yesTópicos, 2013
In this article I seek to show how, for Alfarabi, the agent intellect is not only giver of cognitive forms for the theoretical reason, but rather it also endow to the practical reason with "voluntary intelligibles".
Rafael Ramón Guerrero
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

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