Results 51 to 60 of about 432,272 (311)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Creativity and Conflict: How theory and practice shape student identities in design education [PDF]

, 2009
By exploring the role of student identities in shaping attitudes to learning, this study asks how design students draw on experience to work across theory and practice.
Christopher New, Jane Tynan, New, Christopher, Tynan, Jane   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Integrating Theory and Practice in Education with Business Games [PDF]

Informing Science: The International Journal of an Emerging Transdiscipline, 2003
The meaningful integration of theoretical knowledge and industrial practice in Masters level programmes is now more than ever vital to ensure that graduates have the required competence in IT and that they are ready to contribute to the organisations that hired them within a short timeframe. It is also crucial in ensuring ongoing industrial support for
Karen Neville, Frédéric Adam
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

INVESTIGATING HIGHER EDUCATION COURSE LEADERSHIP PRACTICE – AN ARGUMENT FOR USING GROUNDED THEORY

Novìtnâ Osvìta, 2023
The study of course leadership in higher education focusses on an understudied area of research, with a limited number of publications discussing the role of the course leader in higher education, and a distinct lack of research on how course leaders in
Nieky van Veggel, Hilary Engward, Philip Howlett   +2 more
doaj   +1 more source

Matterings of knowing and doing: sociomaterial approaches to understanding practice [PDF]

, 2012
Discussions of practice, particularly those focused on learning, tend to focus more upon the socio-cultural and socio-political aspects of practice activity than on the actual materiality of practice.
Tara Fenwick, Fenwick, Tara
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Theory and practice of modeling gerontological education

SHS Web of Conferences, 2016
On the basis of the basic principles of andragogy and famous models of education A model of education space on the basis of the basic principles of andragogy and famous models of education, created on the basis of a non-state University to persons of the
Lomakina Tatiana Y.
doaj   +1 more source