Results 71 to 80 of about 428,046 (311)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Transforming education and professional practice

, 2016
In this chapter, we return to the notion of exploring education and professional practices, the key focus of this volume. In the opening chapter, we argued that the theory of practice architectures is simultaneously a theoretical, an analytical, and a ...
Mahon, Kathleen,, Susanne Francisco, Kathleen Mahon, Stephen Kemmis, Francisco, SL, Mahon, K, Francisco, Susanne,, Kemmis, Stephen,, Kemmis, S   +8 more
core   +1 more source

The Role of Visual Feedback on Power Output During Intermittent Wingate Testing in Ice Hockey Players

Sports, 2018
Background: Visual feedback may help elicit peak performance during different types of strength and power testing, but its effect during the anaerobic Wingate test is unexplored.
Petr Stastny, James J. Tufano, Jan Kregl, Miroslav Petr, Dusan Blazek, Michal Steffl, Robert Roczniok, Milos Fiala, Artur Golas, Piotr Zmijewski   +9 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Place-Based Education Is an Intergenerational Practice [PDF]

, 2011
This article makes theoretical links between place-based education and intergenerational learning supported by an analysis of data from an empirical study. The paper argues that school-linked place-based education does more than provide opportunities for
Mannion, Greg, Adey, Claire
core  

AI Literacy: Elementary and Secondary Teachers’ Use of AI-Tools, Reported Confidence, and Professional Development Needs

Education Sciences
The development of artificial intelligence (AI) has had a significant impact on various sectors, including education. The successful integration of AI tools in classrooms depends largely on teachers’ understanding and knowledge, confidence, and training.
Zoi A. Traga Philippakos, Louis Rocconi
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Generative AI for Culturally Responsive Science Assessment: A Conceptual Framework

Education Sciences
In diverse classrooms, one of the challenges educators face is creating assessments that reflect the different cultural backgrounds of every student.
Matthew Nyaaba, Xiaoming Zhai, Morgan Z. Faison   +2 more
doaj   +1 more source

Theory and practice of family education in Germany [PDF]

Sociální Pedagogika
Family education is a dynamic academic field in Germany designed to meet parents' needs. The article aims to present the theory and practice of the field, which lies at the intersection of social education and lifelong adult learning.
Kateřina Neubauerová
doaj   +1 more source