Results 81 to 90 of about 428,046 (311)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Theory and Practice of Modern Domestic Preschool Education
Психологическая наука и образование, 2015 The author marked the most important theoretical principles of cultural-historical psychology and activity approach, which underlie the educational standard.
Burlakova I. A.
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Theory and Practice in Education
British Journal of Educational Studies, 1986 John Andrews, R. F. Dearden
+6 more sources
Variability in Language and Literacy Outcomes Among Deaf Elementary Students in a National Sample
Behavioral SciencesThis study examined the literacy outcomes of 368 deaf elementary students in the United States, focusing on reading and writing performance and their connections with demographic and language variables.
Kimberly Wolbers +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Theory and practice of modular education in Russian education
Perspectives of science and EducationIntroduction. Over the past six decades, modular education has been an important didactic approach in modern international and domestic education, and is one of the factors of its development. The purpose of the article is to characterize this important scientific phenomenon, which has a significant impact on the nature and quality of general and ...
Pomelov, Vladimir B. +2 more
openaire +2 more sources
Middle Level Teacher Development for Advocacy: A Systematic Review of the Literature
Education SciencesIn the realm of middle level education, advocacy is an integral aspect of school culture and community. Advocacy helps to foster a school environment characterized by a sense of respect and value for young adolescents and should take up an awareness of ...
Kristie W. Smith +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Reconceptualising outdoor adventure education: Activity in search of an appropriate theory.
, 2009 Experiential approaches to learning underpin teaching and learning strategies in outdoor adventure education (OAE). Recent critiques of experiential learning have problematised the individualistic and overly cognitive focus of this approach which creates
Brown, Mike
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