Results 111 to 120 of about 152,877 (259)

SELF-ORGANIZATION AND THE THEORY OF EVOLUTION [PDF]

Filozofia i Nauka
The author distinguishes three types of evolutionary theories: 1) ahistorical theories, constructed according to the methodological patterns of classical physics (mechanics), 2) supra-historical theories, in which the historical nature of the ...
Czesław Nowiński
doaj   +1 more source

The evolution of the universe : conflicting modern theories [PDF]

, 1972
It is the purpose of this thesis to present a study of the conflicting aspects of the two major twentieth-century cosmological theories, the Steady State Theory and the Evolutionary Theory. Further, the study was directed toward a decision as to which of
Ingram, Ned Carleton, NC DOCKS at The University of North Carolina at Greensboro   +1 more
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The evolution of different forms of sociality : behavioral mechanisms and eco-evolutionary feedback [PDF]

, 2015
This research was funded by the Netherlands Organization for Scientific Research (http://www.nwo.nl/en): Vici grant NWO-277-80-001 awarded to Rineke Verbrugge (in the project Cognitive systems in interaction: Logical and computational models of higher ...
Verbrugge, Rineke, Hemelrijk, Charlotte, van der Post, Daniel J, Charlotte K. Hemelrijk (160986), Hemelrijk, Charlotte K; id_orcid, Charlotte K Hemelrijk, Rineke Verbrugge (131727), Daniel J van der Post, van der Post Daniel J., Rineke Verbrugge, Hemelrijk Charlotte K., Van Der Post, Daniel Job, Daniel J. van der Post (202025), Hemelrijk, Charlotte K, Verbrugge Rineke   +14 more
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EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Richard Dawkins’te Evrim Teorisinin Natüralistik Yorumu

Kocaeli İlahiyat Dergisi
Evrim teorisi Charles Darwin tarafından ortaya konulduktan sonra farklı felsefi paradigmalar ekseninde yorumlanmıştır. Bu yorumlamalardan en önemlileri, iki ayrı kutbu temsil eden akıllı tasarımcılar ve doğalcı-natüralist ekol olarak öne çıkmaktadır ...
Enes Başıbüyük
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Application of Graph Theory and Automata Modeling for the Study of the Evolution of Metabolic Pathways with Glycolysis and Krebs Cycle as Case Studies

, 2023
Today, graph theory represents one of the most important modeling techniques in biology. One of the most important applications is in the study of metabolic networks. During metabolism, a set of sequential biochemical reactions takes place, which convert
Morenas Mateos, Carlos de Las, Lahoz Beltra, Rafael   +1 more
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Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Capital Theory: Neoclassical and Austrian Perspectives

, 2018
What can be learned from the Austrian theory of capital? Why an objective evaluation of capital's value at the aggregate level?
Valerio Filoso
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Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source