FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Perturbation theory for evolution of cooperation on networks. [PDF]
J Math Biol, 2023 Meng L, Masuda N.
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Samorozumienie nowoczesnego człowieka w świetle ewolucji (Self-understanding of the modern man from the perspective of evolution) [PDF]
Analiza i Egzystencja, 2012 Anthropology and hermeneutics, two disciplines separated in the 19th century, were combined in the 20th. According to them is man a being who interprets itself. This purely formal description has to be filled up with content. How man sees himself depends
Ferdinad Fellmann
doaj
Understanding and acceptance of the theory of evolution in high school students in Mexico. [PDF]
PLoS One, 2023 Salazar-Enriquez G +2 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Sustainability of Human Ecological Niche Construction
Ecology and Society, 2014 Humans influence and depend on natural systems worldwide, creating complex societal-ecological feedbacks that make it difficult to assess the long-term sustainability of contemporary human activities.
Forest Isbell, Michel Loreau
doaj +1 more source
Toward a theory of evolution as multilevel learning. [PDF]
Proc Natl Acad Sci U S A, 2022 Vanchurin V +3 more
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Racial misconceptions of the theory of evolution predict opposition to the theory and science in general among a sample of Zimbabwean university students. [PDF]
Heliyon, 2023 Chisango T +6 more
europepmc +1 more source