Results 131 to 140 of about 512,183 (308)

Regionalisms and the ‘exceptionality’ of security regions

open access: yesNordia Geographical Publications, 2015
Work on regions and regionalisms highlights the complex processes through which regions emerge or disappear, or are remade often with unpredictable outcomes.
Maano Ramutsindela
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

A model of the Keynesian theory for Portugal [PDF]

open access: yes
With this work we try to present a model for Portugal based on the Keynesian theory. We built the model taking into account the Verdoorn Law, with the alternative specifications of (1)Kaldor (1966), for the five Portuguese regions (NUTS II) and from 1986
Martinho, Vítor João Pereira Domingues
core   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

A model of the Keynesian theory for Portugal. Another perspective [PDF]

open access: yes
With this work we try to present a model for Portugal based on the Keynesian theory. We built the model taking into account the Verdoorn Law, with the alternative specifications of (1)Kaldor (1966), for the twenty eight Portuguese regions (NUTS III) and ...
Martinho, Vítor João Pereira Domingues
core   +1 more source

Challenges of integrating HIV prevention and treatment in China's border mountain regions: a grounded theory study

open access: yesBMC Infectious Diseases
Background HIV remains a critical global public health challenge, with 39 million people living with HIV as of 2022 and over 40.4 million lives lost to the epidemic. In China, the burden is similarly significant, with over 1.33 million HIV cases reported
Sixian Du   +10 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Resilient Regions: Clarity of Concepts and Challenges to Systemic Measurement [PDF]

open access: yes
Dealing with perturbations such as economic crises, pandemics and climate change requires an understanding of the resilience and vulnerability of regions.
Yiheyis T Maru
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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