Results 131 to 140 of about 2,758,604 (298)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Determinants of the industrial location in Peru, 1963-1974
EconomíaThe present study responds to the following question: What factors determined the location of manufacturing industries in Peruvian regions for the years 1963 and 1974? Using the data of the Economic Censuses conducted in 1963 and 1974 by the Peruvian
Gonzalo Rivera Mariscal
doaj +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Anali Hrvatskog Politološkog Društva, 2007 The author analyses the flaws of the multilevel governance theory, which seeks to assert itself as a dominant theory of European integration. The multilevel governance theory begun its life in the work of Gary Marks, who juxtaposed it to functionalist ...
Dario Nikić Čakar
doaj
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
THEORIES OF ECONOMIC DEVELOPMENT OF REGIONS
The bulletin of transport and industry economics, 2023 The article provides an analytical overview of the main theories of regional economic development, which guided the strategies and programs of regional economic development introduced during the last decades. The relevance of the research has four aspects. First, it is to determine the main features of each theory.
openaire +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Regionalisms and the ‘exceptionality’ of security regions
Nordia Geographical Publications, 2015 Work on regions and regionalisms highlights the complex processes through which regions emerge or disappear, or are remade often with unpredictable outcomes.
Maano Ramutsindela
doaj
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source