Results 121 to 130 of about 174,044,778 (302)

Determinants of the industrial location in Peru, 1963-1974

Economía
The present study responds to the following question: What factors determined the location of manufacturing industries in Peruvian regions for the years 1963 and 1974? Using the data of the Economic Censuses conducted in 1963 and 1974 by the Peruvian
Gonzalo Rivera Mariscal
doaj   +1 more source

The Theory of Geographical Region

Geografie, 1966
When evaluating the state of the theoretical understanding of the geographical region we come to conclusions similar to those arrived at when evaluating the whole geographical theory. Vagueness and uncertainty in basic problems, diversity of opinions, an unsystematic character of research - these are characteristic features of the geographical theory ...
openaire   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Comparing Sectoral Investment and Employment Specialisation of EU Regions: A Spatial Econometric Analysis [PDF]

EMU is accompanied by increased market integration and factor mobility ? especially of the production factor capital. Up to date, there is no clear indication concerning the specialisation tendencies to be expected due to these impacts.
Claudia Stirboeck
core  

Regionalisms and the ‘exceptionality’ of security regions

Nordia Geographical Publications, 2015
Work on regions and regionalisms highlights the complex processes through which regions emerge or disappear, or are remade often with unpredictable outcomes.
Maano Ramutsindela
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Challenges of integrating HIV prevention and treatment in China's border mountain regions: a grounded theory study

BMC Infectious Diseases
Background HIV remains a critical global public health challenge, with 39 million people living with HIV as of 2022 and over 40.4 million lives lost to the epidemic. In China, the burden is similarly significant, with over 1.33 million HIV cases reported
Sixian Du, Haoran Niu, Feng Jiang, Liwen Gong, Shan Zheng, Qi Cui, Xu Yang, Jiayan He, Rongcai Dai, Qilian Luo, Yiqing Yang   +10 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Seismic exploration in cold regions

, 2020
COLD REGIONS SCIENCE AND ENGINEERING Mo n og ra p h l l-A2a c. / H-A2a SEISMIC EXPLORATION IN COLD REGIONS Hans Roethl isberger October 1 972 CORPS OF ENGINEERS, U.S.
Cold Regions Research and Engineering Laboratory (U.S.)
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source