Results 111 to 120 of about 512,183 (308)

Application of reliability theory and risk management in sustainable agricultural construction infrastructure in high-risk regions

Budownictwo o Zoptymalizowanym Potencjale Energetycznym
Reliability theory, probabilistic modeling, and risk management are tools that allow for deter-mining the probability of correct operation under specific times and conditions, better under-standing complex real-world systems by accounting for their ...
Martin Vartanov, Nana Beraia, Konstantine Bziava, Marina Shogiradze   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A model of the Keynesian theory for the Portuguese manufactured industry [PDF]

With this work we try to present a model for the Portuguese manufactured industry based on the Keynesian theory. We built the model testing the Verdoorn Law, with the alternative specifications of (1)Kaldor (1966), for the five Portuguese regions (NUTS ...
Martinho, Vítor João Pereira Domingues
core   +1 more source

A Systematic Approach for the Conservation and Sustainable Activation of Traditional Military Settlements Using TRIZ Theory: A Case Study of Zhenjing Village, Arid Northern China

Buildings
This study aims to examine the methodological applicability of the Theory of Inventive Problem Solving (TRIZ) in the conservation and revitalization of traditional military settlements.
Hubing Li, Feng Zhao, Haitao Ren
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

THE EXPECTED CONVEX HULL TRIMMED REGIONS OF A SAMPLE [PDF]

Given a data set in the multivariate Euclidean space, we study regions of central points built by averaging all their subsets with a fixed number of elements.
Ignacio Cascos
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A model of the Keynesian theory for the Portuguese manufactured industry. Another analysis [PDF]

With this work we try to present a model for the Portuguese manufactured industry based on the Keynesian theory. We built the model testing the Verdoorn Law, with the alternative specifications of (1)Kaldor (1966), for the five Portuguese regions (NUTS ...
Martinho, Vítor João Pereira Domingues
core   +1 more source

An empirical note on growth and convergence across Russian regions [PDF]

This empirical note uses publicly available Goskomstat data to investigate income growth and convergence across Russian regions. Using data for 1992-2001, we find strong sigma divergence simultaneously with beta convergence.
Laura Solanko
core   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source