Results 111 to 120 of about 2,758,604 (298)

The Theory of Geographical Region

Geografie, 1966
When evaluating the state of the theoretical understanding of the geographical region we come to conclusions similar to those arrived at when evaluating the whole geographical theory. Vagueness and uncertainty in basic problems, diversity of opinions, an unsystematic character of research - these are characteristic features of the geographical theory ...
openaire   +1 more source

A model of the Keynesian theory for the Portuguese manufactured industry. Another analysis [PDF]

With this work we try to present a model for the Portuguese manufactured industry based on the Keynesian theory. We built the model testing the Verdoorn Law, with the alternative specifications of (1)Kaldor (1966), for the five Portuguese regions (NUTS ...
Martinho, Vítor João Pereira Domingues
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Systemic Foundations of Regional Theory

, 2023
Resumen:  La teoría y la política regionales están en tensión por la revelación de deficiencias de los sistemas convencionales para tratar con problemas propios  de la formación social de los países no centrales, que descubren contradicciones de los más avanzados.
openaire   +1 more source

Economic Geography and Spatial Statistics: Theory and Empirics of New Zealand Regions [PDF]

This paper sets the stage for current Treasury research on New Zealand regional socio-economic issues by: - Outlining a basic theoretical framework; - Introducing a regional database and Geographic Information Systems, a new empirical tool for data ...
Jason Timmins, Suzi Kerr
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Prediction and Evaluation of Road Service Performance in Cold Regions Based on Uncertainty Quantification Theory

Zhongwai Gonglu
In cold regions, road service performance is influenced by various nonlinear dynamic factors under complex hydrothermal environments and freeze-thaw cycles.
LIU Yuanyuan, SI Junling, ZHENG Hao, REN Daoju, FAN Shaobing, QUAN Lei   +5 more
doaj   +1 more source

A model of the Keynesian theory for Portugal [PDF]

With this work we try to present a model for Portugal based on the Keynesian theory. We built the model taking into account the Verdoorn Law, with the alternative specifications of (1)Kaldor (1966), for the five Portuguese regions (NUTS II) and from 1986
Martinho, Vítor João Pereira Domingues
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source