Results 111 to 120 of about 511,832 (308)

A Systematic Approach for the Conservation and Sustainable Activation of Traditional Military Settlements Using TRIZ Theory: A Case Study of Zhenjing Village, Arid Northern China

open access: yesBuildings
This study aims to examine the methodological applicability of the Theory of Inventive Problem Solving (TRIZ) in the conservation and revitalization of traditional military settlements.
Hubing Li, Feng Zhao, Haitao Ren
doaj   +1 more source

THE EXPECTED CONVEX HULL TRIMMED REGIONS OF A SAMPLE [PDF]

open access: yes
Given a data set in the multivariate Euclidean space, we study regions of central points built by averaging all their subsets with a fixed number of elements.
Ignacio Cascos
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

An empirical note on growth and convergence across Russian regions [PDF]

open access: yes
This empirical note uses publicly available Goskomstat data to investigate income growth and convergence across Russian regions. Using data for 1992-2001, we find strong sigma divergence simultaneously with beta convergence.
Laura Solanko
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Determinants of the industrial location in Peru, 1963-1974

open access: yesEconomía
The present study responds to the following question: What factors determined the location of manufacturing industries in Peruvian regions for the years 1963 and 1974? Using the data of the Economic Censuses conducted in 1963 and 1974 by the Peruvian
Gonzalo Rivera Mariscal
doaj   +1 more source

Adaptive Localization Regions for O(N) Density Functional Theory [PDF]

open access: yes, 2008
A linear scaling approach for general and accurate pseudopotential Density Functional Theory calculations is presented. It is based on a Finite Difference discretization.
Fattebert, J
core  

Efficient Calculations of Molecular Linear Response Properties for Spectral Regions

open access: yes, 2014
Molecular spectra can be determined from molecular response functions, by solving the so-called damped response equations using the complex polarization propagator approach.
Kauczor, Joanna,, Norman, Patrick,
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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