Results 91 to 100 of about 512,183 (308)
BMC Infectious DiseasesBackground This study aimed to investigate the global and nodal functional network alterations, abnormal connections of brain regions, and potential imaging biomarkers in virally suppressed people living with HIV (PLH) with asymptomatic neurocognitive ...
Xire Aili +10 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
On Achievable Rate Regions for Source Coding Over Networks [PDF]
, 2009 In the field of source coding over networks, a central goal is to understand the best possible performance for compressing and transmitting dependent data distributed over a network.
Gu, WeiHsin
core +1 more source
The Theory of Geographical Region
Geografie, 1966 When evaluating the state of the theoretical understanding of the geographical region we come to conclusions similar to those arrived at when evaluating the whole geographical theory. Vagueness and uncertainty in basic problems, diversity of opinions, an unsystematic character of research - these are characteristic features of the geographical theory ...
openaire +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Comparing Sectoral Investment and Employment Specialisation of EU Regions: A Spatial Econometric Analysis [PDF]
EMU is accompanied by increased market integration and factor mobility ? especially of the production factor capital. Up to date, there is no clear indication concerning the specialisation tendencies to be expected due to these impacts.
Claudia Stirboeck
core
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
What said the economic theory about Portugal [PDF]
This work aims to test the Verdoorn Law, with the alternative specifications of (1)Kaldor (1966), for five Portuguese regions (NUTS II) from 1986 to 1994.
Martinho, Vítor João Pereira Domingues
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source