Results 91 to 100 of about 511,832 (308)
Comparing Sectoral Investment and Employment Specialisation of EU Regions: A Spatial Econometric Analysis [PDF]
EMU is accompanied by increased market integration and factor mobility ? especially of the production factor capital. Up to date, there is no clear indication concerning the specialisation tendencies to be expected due to these impacts.
Claudia Stirboeck
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
The Theory of Geographical Region
Geografie, 1966 When evaluating the state of the theoretical understanding of the geographical region we come to conclusions similar to those arrived at when evaluating the whole geographical theory. Vagueness and uncertainty in basic problems, diversity of opinions, an unsystematic character of research - these are characteristic features of the geographical theory ...
openaire +1 more source
Convergence across countries and regions: theory and empirics [PDF]
This paper surveys the recent literature on convergence across countries and regions. I discuss the main convergence and divergence mechanisms identified in the literature and develop a simple model that illustrates their implications for income dynamics.
Angel de la Fuente
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Unemployment Clusters Across European Regions and Countries [PDF]
European regions have experienced a polarisation of their unemployment rates between 1986 and 1996, as regions with intermediate rates have been driven by changes in regional employment, only partly offset by labour force changes.
Diego Puga, Henry Overman
core
Introducing the Field : Conspiracy Theory in, about, and as Religion
, 2018 Conspiracy theory and religion are complex phenomena. The relationship between them varies. This chapter introduces some of these relations, highlighting conspiracy theory in, about, and as religion.
Dyrendal, Asbjørn +2 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source