Results 101 to 110 of about 511,832 (308)
Zhongwai GongluIn cold regions, road service performance is influenced by various nonlinear dynamic factors under complex hydrothermal environments and freeze-thaw cycles.
LIU Yuanyuan +5 more
doaj +1 more source
Specialization and growth patterns in border regions of accession countries [PDF]
This paper aims at exploring and analysing on a comparative basis the impact of the East enlargement of the EU on border regions in Bulgaria, Estonia, Hungary, Romania and Slovenia.
Resmini, Laura
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
European integration and adjustment in border regions in accession countries [PDF]
Border regions in accession countries are not the exception but the rule, since they cover almost 66% of the land and account for 58% of total population.
Resmini, Laura
core
Corotating interaction regions as seen by the STEREO Heliospheric Imagers 2007 – 2010
, 2015 T.M. Conlon and A.O. Williams were supported by an STFC, UK studentship and S.E. Milan was supported by STFC grant ST/K001000/1. Date of Acceptance: 08/08/2015NASA’s Solar Terrestrial Relations Observatory (STEREO) mission has coincided with a pronounced
J. A. Davies +7 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A model of the Keynesian theory for Portugal. Another approach
With this work we try to present an alternative model for Portugal based on the Keynesian theory. We built the model testing the validity of the well known “Verdoorn´s Law” which considers the relationship between the growth of productivity and output in
Martinho, Vítor João Pereira Domingues
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source