Results 101 to 110 of about 242,723 (257)

Einstein, Gödel, Heidegger. Some observations about the concept of time

open access: yesPensamiento. Revista de Investigación e Información Filosófica, 2013
In this article we focus on some of the paths which help us to understand the philosophical question of time. The interpretative frame is composed of Einstein’s theory of relativity, against which we have the observations of Gödel and Heidegger on this ...
Diego Malquori
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Quantum Gravity as a Broken Symmetry Phase of a BF Theory

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2006
We explain how General Relativity with a cosmological constant arises as a broken symmetry phase of a BF theory. In particular we show how to treat de Sitter and anti-de Sitter cases simultaneously.
Aleksandar Miković
doaj  

Can Lorentz transformations be determined by the null Michelson-Morley result?

open access: yesRevista Brasileira de Ensino de Física
The so-called principle of relativity is able to fix a general coordinate transformation which differs from the standard Lorentzian form only by an unknown speed which cannot in principle be identified with the light speed.
J. A. S. Lima, Fernando D. Sasse
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Einstein e la sindrome ionica. Oltre la relatività generale, la ricerca di una teoria unitaria di campo continuo [PDF]

open access: yesS&F_scienzaefilosofia.it, 2016
Einstein and the ionic Syndrome. Searching for a unified Theory of continuum Field beyond the general Relativity In Physics and Reality (1936), Albert Einstein wrote about his General Theory of Relativity: “It is similar to a building, one wing of which
Pietro Greco
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

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