Results 81 to 90 of about 2,791,202 (312)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

CMB, Hawking, Planck, and Hubble Scale Relations Consistent with Recent Quantization of General Relativity Theory

International Journal of Theoretical Physics
We are demonstrating new relationships among the Hawking temperature, the Cosmic Microwave Background (CMB) temperature, and the Planck scale. When understood deeply, these are in line with recent advancements in cosmological quantization and its ...
E. Haug
semanticscholar   +1 more source

Teaching general relativity theory in high school: why, what and how

Revista de Enseñanza de la Física, 2017
In this work, which is part of a wider research, the problem of teaching the General Theory of Relativity in sec-ondary school is addressed, even though this theory is scarcely addressed even in physics degree courses.
Irene Arriassecq, Esther Cayul, Ileana M. Greca   +2 more
doaj  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

An Alternate Theory of Special Relativity and Relativistic Mass

Open access journal of physics, 2019
A theory is proposed to replace the mechanics of the special theory of relativity (STR). It is required that this theory must closely resemble Newtonian mechanics at low velocities and yet have relativistic properties at high velocities, which at a ...
Sc.D Donald Aucamp
semanticscholar   +1 more source

On relative separability in hypergraphs of models of theories [PDF]

arXiv, 2018
In the paper, notions of relative separability for hypergraphs of models of a theory are defined. Properties of these notions and applications to ordered theories are studied: characterizations of relative separability both in a general case and for almost countably categorical quite o-minimal theories are established.
arxiv  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Ternary relative velocity; astonishing conflict of the Lorentz group with relativity [PDF]

arXiv, 2011
We are proving that the Lorentz boost entails the relative velocity to be ternary: ternary relative velocity is a velocity of a body with respect to an interior observer as seen by a preferred exterior-observer. The Lorentz boosts imply non-associative addition of ternary relative velocities.
arxiv