Results 31 to 40 of about 2,878,819 (307)
Antibodies, 2022 This report describes the discovery and characterization of antibodies with potential broad SARS-CoV-2 neutralization profiles. The antibodies were obtained from a phage display library built with the VH repertoire of a convalescent COVID-19 patient who ...
Ivette Mendoza-Salazar +8 more
doaj +1 more source
Results in ChemistryThe identification of biological products, such as vaccines, blood components and recombinant therapeutic proteins, involve diverse challenges. This study introduces a novel method that employs Raman spectroscopy with a transformer model enhanced by ...
Jin Ling +4 more
doaj +1 more source
Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs?
Frontiers in Pharmacology, 2020 Model-informed precision dosing (MIPD) software tools are used to optimize dosage regimens in individual patients, aiming to achieve drug exposure targets associated with desirable clinical outcomes.
Wannee Kantasiripitak +10 more
doaj +1 more source
The immunogenicity of human-origin therapeutic antibodies are associated with V gene usage
Frontiers in Immunology, 2023 Therapeutic antibodies can elicit unwanted immune responses in a subset of patients, which leads to the production of anti-drug antibodies (ADA).
Zicheng Hu +2 more
doaj +1 more source
New structural formats of therapeutic antibodies for rheumatology
, 2018 International audiencePharmaceutical companies strive continuously to develop better medications in order to remain competitive. In the arena of monoclonal antibodies and related biologics (fusion proteins containing an IgG Fc fragment), the thrust is ...
Jérémy Pottier +7 more
core +1 more source
Therapeutic Monoclonal Antibodies
The Keio Journal of Medicine, 2011 Over a hundred years has passed since the discovery of the "magic bullet" serum therapy by Kitasato and Behring, the first ever therapeutic use of antibodies. More than 80 years later, the investigation of immunoglobulin structure and function and the development of cell and molecular biology introduced the production of monoclonal antibodies (MoAbs ...
openaire +3 more sources
Avian Antibodies as Potential Therapeutic Tools. [PDF]
Immunoglobulin Y (IgY) is the primary antibody found in the eggs of chicken (Gallus domesticus), allowing for large-scale antibody production with high titers, making them cost-effective antibody producers.
Eriksson, Mats, +5 more
core +1 more source
Anti-neurofascin antibodies [PDF]
, 2012 Neurofascin (NF) is a cell-adhesion molecule that is found at the nodes of Ranvier. The 186 kDa isoform of neurofascin (NF186) is expressed on the axon in the exposed node, and the 155 kDa isoform (NF155) is expressed on myelinating glia at the ...
Ng, King Man
core +1 more source
Hepatitis C virus evasion mechanisms from neutralizing antibodies [PDF]
, 2011 Hepatitis C virus (HCV) represents a major public health problem, affecting 3% of the world’s population. The majority of infected individuals develop chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma.
Angus, Allan G.N. +5 more
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Current perspectives on therapeutic antibodies
, 2021 Since the first monoclonal antibody, muromonab-CD3, was approved for therapeutic use in 1986, numerous molecules have been targeted using therapeutic antibody technology, resulting in 26 therapeutic antibodies being approved by the US FDA as of November,
심현보
core +1 more source