Results 11 to 20 of about 901,780 (213)

Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice

Pharmaceutics, 2023
DNA-based antibody therapy seeks to administer the encoding nucleotide sequence rather than the antibody protein. To further improve the in vivo monoclonal antibody (mAb) expression, a better understanding of what happens after the administration of the ...
Marie-Lynn Cuypers, Nick Geukens, Kevin Hollevoet, Paul Declerck, Maarten Dewilde   +4 more
doaj   +1 more source

Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies

Molecular Therapy: Methods & Clinical Development, 2023
Over the last decade, there has been a growing interest in intrabodies and their therapeutic potential. Intrabodies are antibody fragments that are expressed inside a cell to target intracellular antigens.
Dina Rodrigues Martins, Fern Sha, Wim Van der Elst, Pei-Yu Shih, Jens Devoght, Kristof Van Kolen, Marc Mercken, Bianca Van Broeck, Paul Declerck, Clara Theunis   +9 more
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Helix Matrix Transformation Combined With Convolutional Neural Network Algorithm for Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry-Based Bacterial Identification

Frontiers in Microbiology, 2020
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis is a rapid and reliable method for bacterial identification.
Jin Ling, Jin Ling, Gaomin Li, Gaomin Li, Hong Shao, Hong Shao, Hong Wang, Hong Wang, Hongrui Yin, Hongrui Yin, Hu Zhou, Yufei Song, Gang Chen, Gang Chen   +13 more
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Novel ELISA for the specific detection of protease NEXIN‐1 in human biological samples

Research and Practice in Thrombosis and Haemostasis, 2022
Introduction Serpin E2 or protease nexin‐1 (PN‐1) is a glycoprotein belonging to the serpin superfamily, whose function is closely linked to its ability to inhibit thrombin and proteases of the plasminergic system.
Laurence Venisse, Déborah François, Célina Madjène, Els Brouwers, Emmanuelle deRaucourt, Yacine Boulaftali, Paul Declerck, Véronique Arocas, Marie‐Christine Bouton   +8 more
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State of play and clinical prospects of antibody gene transfer

Journal of Translational Medicine, 2017
Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high product cost and prolonged need for frequent
Kevin Hollevoet, Paul J. Declerck
doaj   +1 more source

Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa

Pharmaceutics, 2021
Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents.
Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gänger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Völk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowski   +15 more
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Combination therapy of therapeutic antibody and vaccine or entecavir in HBV carrier mice

Frontiers in Microbiology, 2023
Chronic infection with the hepatitis B virus (HBV) is a leading causes of liver cirrhosis and hepatocellular carcinoma. However, managing HBV treatments is challenging due to the lack of effective monotherapy. Here, we present two combination approaches,
Ruoyao Qi, Ruoyao Qi, Jiali Cao, Yangtao Wu, Yangtao Wu, Xing Lei, Xing Lei, Jinhang He, Jinhang He, Liang Zhang, Liang Zhang, Rao Fu, Rao Fu, Feng Chen, Feng Chen, Yingbin Wang, Yingbin Wang, Tianying Zhang, Tianying Zhang, Ningshao Xia, Ningshao Xia, Quan Yuan   +21 more
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Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs?

Frontiers in Pharmacology, 2020
Model-informed precision dosing (MIPD) software tools are used to optimize dosage regimens in individual patients, aiming to achieve drug exposure targets associated with desirable clinical outcomes.
Wannee Kantasiripitak, Ruth Van Daele, Ruth Van Daele, Matthias Gijsen, Matthias Gijsen, Marc Ferrante, Marc Ferrante, Isabel Spriet, Isabel Spriet, Erwin Dreesen, Erwin Dreesen   +10 more
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Anti-SARS-CoV-2 Omicron Antibodies Isolated from a SARS-CoV-2 Delta Semi-Immune Phage Display Library

Antibodies, 2022
This report describes the discovery and characterization of antibodies with potential broad SARS-CoV-2 neutralization profiles. The antibodies were obtained from a phage display library built with the VH repertoire of a convalescent COVID-19 patient who ...
Ivette Mendoza-Salazar, Keyla M. Gómez-Castellano, Edith González-González, Ramsés Gamboa-Suasnavart, Stefany D. Rodríguez-Luna, Giovanni Santiago-Casas, María I. Cortés-Paniagua, Sonia M. Pérez-Tapia, Juan C. Almagro   +8 more
doaj   +1 more source

The immunogenicity of human-origin therapeutic antibodies are associated with V gene usage

Frontiers in Immunology, 2023
Therapeutic antibodies can elicit unwanted immune responses in a subset of patients, which leads to the production of anti-drug antibodies (ADA).
Zicheng Hu, Sivan Cohen, Steven J. Swanson   +2 more
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