Results 11 to 20 of about 45,745 (258)

Antibody Engineering for the Development of Therapeutic Antibodies

Molecules and Cells, 2005
Therapeutic antibodies represent one of the fastest growing areas of the pharmaceutical industry. There are currently 19 monoclonal antibodies in the market that have been approved by the FDA and over 150 in clinical developments. Driven by innovation and technological developments, therapeutic antibodies are the second largest biopharmaceutical ...
Sang Jick, Kim, Youngwoo, Park, Hyo Jeong, Hong   +2 more
core   +5 more sources

Alternative Routes of Administration for Therapeutic Antibodies—State of the Art

Antibodies, 2022
Background: For the past two decades, there has been a huge expansion in the development of therapeutic antibodies, with 6 to 10 novel entities approved each year.
Aubin Pitiot, Nathalie Heuzé-Vourc’h, Thomas Sécher   +2 more
doaj   +2 more sources

Bispecific antibodies: design, therapy, perspectives

Drug Design, Development and Therapy, 2018
Sergey E Sedykh, Victor V Prinz, Valentina N Buneva, Georgy A Nevinsky Laboratory of Repair Enzymes, Siberian Branch of Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, Novosibirsk State University, Novosibirsk, Russia
Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA   +3 more
doaj   +1 more source

Fc-Engineered Therapeutic Antibodies: Recent Advances and Future Directions [PDF]

, 2023
Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance the effector functions or half-life of therapeutic antibodies by modifying their Fc regions.
Dalia T. Abdeldaim, Abdeldaim, Dalia T, Schindowski, Katharina, Katharina Schindowski   +3 more
core   +1 more source

A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape

Biomedicines, 2022
CD73 catalyzes the conversion of ATP to adenosine, which is involved in various physiological and pathological processes, including tumor immune escape.
Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler   +6 more
doaj   +1 more source

Monoclonal Antibodies as Neurological Therapeutics [PDF]

Pharmaceuticals, 2021
Over the last 30 years the role of monoclonal antibodies in therapeutics has increased enormously, revolutionizing treatment in most medical specialties, including neurology. Monoclonal antibodies are key therapeutic agents for several neurological conditions with diverse pathophysiological mechanisms, including multiple sclerosis, migraines and ...
Panagiotis Gklinos, Miranta Papadopoulou, Vid Stanulovic, Dimos D. Mitsikostas, Dimitrios Papadopoulos   +4 more
openaire   +4 more sources

Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice

Pharmaceutics, 2023
DNA-based antibody therapy seeks to administer the encoding nucleotide sequence rather than the antibody protein. To further improve the in vivo monoclonal antibody (mAb) expression, a better understanding of what happens after the administration of the ...
Marie-Lynn Cuypers, Nick Geukens, Kevin Hollevoet, Paul Declerck, Maarten Dewilde   +4 more
doaj   +1 more source

Anti-tau intrabodies: From anti-tau immunoglobulins to the development of functional scFv intrabodies

Molecular Therapy: Methods & Clinical Development, 2023
Over the last decade, there has been a growing interest in intrabodies and their therapeutic potential. Intrabodies are antibody fragments that are expressed inside a cell to target intracellular antigens.
Dina Rodrigues Martins, Fern Sha, Wim Van der Elst, Pei-Yu Shih, Jens Devoght, Kristof Van Kolen, Marc Mercken, Bianca Van Broeck, Paul Declerck, Clara Theunis   +9 more
doaj   +1 more source

Helix Matrix Transformation Combined With Convolutional Neural Network Algorithm for Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry-Based Bacterial Identification

Frontiers in Microbiology, 2020
Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis is a rapid and reliable method for bacterial identification.
Jin Ling, Jin Ling, Gaomin Li, Gaomin Li, Hong Shao, Hong Shao, Hong Wang, Hong Wang, Hongrui Yin, Hongrui Yin, Hu Zhou, Yufei Song, Gang Chen, Gang Chen   +13 more
doaj   +1 more source

Novel ELISA for the specific detection of protease NEXIN‐1 in human biological samples

Research and Practice in Thrombosis and Haemostasis, 2022
Introduction Serpin E2 or protease nexin‐1 (PN‐1) is a glycoprotein belonging to the serpin superfamily, whose function is closely linked to its ability to inhibit thrombin and proteases of the plasminergic system.
Laurence Venisse, Déborah François, Célina Madjène, Els Brouwers, Emmanuelle deRaucourt, Yacine Boulaftali, Paul Declerck, Véronique Arocas, Marie‐Christine Bouton   +8 more
doaj   +1 more source