Results 11 to 20 of about 2,878,819 (307)
Development of Therapeutic Antibodies and Modulating the Characteristics of Therapeutic Antibodies to Maximize the Therapeutic Efficacy [PDF]
Biotechnology and Bioprocess Engineering, 2021 Monoclonal antibodies (mAb) have been used as therapeutic agents for various diseases, and immunoglobulin G (IgG) is mainly used among antibody isotypes due to its structural and functional properties. So far, regardless of the purpose of the therapeutic antibody, wildtype IgG has been mainly used, but recently, the engineered antibodies with various ...
Kang, Seung Hyun, Lee, Chang-Han
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Bispecific antibodies: design, therapy, perspectives
Drug Design, Development and Therapy, 2018 Sergey E Sedykh, Victor V Prinz, Valentina N Buneva, Georgy A Nevinsky Laboratory of Repair Enzymes, Siberian Branch of Russian Academy of Sciences Institute of Chemical Biology and Fundamental Medicine, Novosibirsk State University, Novosibirsk, Russia
Sedykh SE +3 more
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Fc-Engineered Therapeutic Antibodies: Recent Advances and Future Directions [PDF]
, 2023 Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance the effector functions or half-life of therapeutic antibodies by modifying their Fc regions.
Dalia T. Abdeldaim +3 more
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Biomedicines, 2022 CD73 catalyzes the conversion of ATP to adenosine, which is involved in various physiological and pathological processes, including tumor immune escape.
Markus Kellner +6 more
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Therapeutic Antibodies in Stroke [PDF]
Translational Stroke Research, 2013 Immunotherapy represents an active area of biomedical research to treat cancer, autoimmune diseases, and neurodegenerative disorders. In stroke, recanalization therapy is effective in reducing brain tissue damage after acute ischemic stroke. However, the narrow time window restricts its application for the majority of stroke patients.
Yu, C.Y, Ng, G, Liao, P
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Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice
Pharmaceutics, 2023 DNA-based antibody therapy seeks to administer the encoding nucleotide sequence rather than the antibody protein. To further improve the in vivo monoclonal antibody (mAb) expression, a better understanding of what happens after the administration of the ...
Marie-Lynn Cuypers +4 more
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Frontiers in Microbiology, 2020 Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis is a rapid and reliable method for bacterial identification.
Jin Ling +13 more
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Monoclonal Antibodies as Neurological Therapeutics [PDF]
Pharmaceuticals, 2021 Over the last 30 years the role of monoclonal antibodies in therapeutics has increased enormously, revolutionizing treatment in most medical specialties, including neurology. Monoclonal antibodies are key therapeutic agents for several neurological conditions with diverse pathophysiological mechanisms, including multiple sclerosis, migraines and ...
Panagiotis Gklinos +4 more
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Molecular Therapy: Methods & Clinical Development, 2023 Over the last decade, there has been a growing interest in intrabodies and their therapeutic potential. Intrabodies are antibody fragments that are expressed inside a cell to target intracellular antigens.
Dina Rodrigues Martins +9 more
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State of play and clinical prospects of antibody gene transfer
Journal of Translational Medicine, 2017 Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high product cost and prolonged need for frequent
Kevin Hollevoet, Paul J. Declerck
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