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Therapeutic Antibodies in Medicine [PDF]

Molecules, 2023
Antibody engineering has developed into a wide-reaching field, impacting a multitude of industries, most notably healthcare and diagnostics. The seminal work on developing the first monoclonal antibody four decades ago has witnessed exponential growth in
Prerna Sharma, Rahul V. Joshi, Robert Pritchard, Kevin Xu, Maya A. Eicher   +4 more
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Editorial: The immune response to therapeutic antibodies [PDF]

Frontiers in Immunology
Michael G. Tovey, Arno J. Kromminga, Daniel T. Mytych   +2 more
doaj   +4 more sources

Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives

Vaccines, 2021
Respiratorytract infections (RTIs) are frequent and life-threatening diseases, accounting for several millions of deaths worldwide. RTIs implicate microorganisms, including viruses (influenza virus, coronavirus, respiratory syncytial virus (RSV ...
Alexie Mayor, Adélaïde Chesnay, Guillaume Desoubeaux, David Ternant, Nathalie Heuzé-Vourc’h, Thomas Sécher   +5 more
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Alternative Routes of Administration for Therapeutic Antibodies—State of the Art

Antibodies, 2022
Background: For the past two decades, there has been a huge expansion in the development of therapeutic antibodies, with 6 to 10 novel entities approved each year.
Aubin Pitiot, Nathalie Heuzé-Vourc’h, Thomas Sécher   +2 more
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Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model

Frontiers in Oncology, 2022
DNA-encoded delivery and in vivo expression of antibody therapeutics presents an innovative alternative to conventional protein production and administration, including for cancer treatment.
Kevin Hollevoet, Kevin Hollevoet, Debby Thomas, Debby Thomas, Griet Compernolle, Griet Compernolle, Giles Vermeire, Elien De Smidt, Elien De Smidt, Stéphanie De Vleeschauwer, Trevor R. F. Smith, Paul D. Fisher, Maarten Dewilde, Maarten Dewilde, Nick Geukens, Paul Declerck, Paul Declerck   +16 more
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Extreme Point Sort Transformation Combined With a Long Short-Term Memory Network Algorithm for the Raman-Based Identification of Therapeutic Monoclonal Antibodies

Frontiers in Chemistry, 2022
Therapeutic monoclonal antibodies (mAbs) are a new generation of protein-based medicines that are usually expensive and thus represent a target for counterfeiters.
Jin Ling, Luxia Zheng, Mingming Xu, Gang Chen, Xiao Wang, Danzhuo Mao, Hong Shao   +6 more
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Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Frontiers in Chemistry, 2022
Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine
Tao Liu, Tao Liu, Tao Liu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Jun Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo, Xinli Zhou, Sheng Hou, Sheng Hou, Sheng Hou   +22 more
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Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics

Pharmaceutics, 2023
The blood-brain barrier (BBB), while being the gatekeeper of the central nervous system (CNS), is a bottleneck for the treatment of neurological diseases.
Laura Rué, Tom Jaspers, Isabelle M. S. Degors, Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde   +6 more
doaj   +1 more source

Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles

Biosafety and Health, 2022
The coronavirus disease 2019 (COVID-19) is still causing a wide range of infections and deaths due to the high variability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Sheng Wang, Lizhen Liu, Can Wang, Ziqiang Wang, Xuhua Duan, Gang Chen, Hu Zhou, Hong Shao   +7 more
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A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape

Biomedicines, 2022
CD73 catalyzes the conversion of ATP to adenosine, which is involved in various physiological and pathological processes, including tumor immune escape.
Markus Kellner, Bettina von Neubeck, Bastian Czogalla, Regina Feederle, Binje Vick, Irmela Jeremias, Reinhard Zeidler   +6 more
doaj   +1 more source