Results 21 to 30 of about 2,878,819 (307)

Novel ELISA for the specific detection of protease NEXIN‐1 in human biological samples

Research and Practice in Thrombosis and Haemostasis, 2022
Introduction Serpin E2 or protease nexin‐1 (PN‐1) is a glycoprotein belonging to the serpin superfamily, whose function is closely linked to its ability to inhibit thrombin and proteases of the plasminergic system.
Laurence Venisse, Déborah François, Célina Madjène, Els Brouwers, Emmanuelle deRaucourt, Yacine Boulaftali, Paul Declerck, Véronique Arocas, Marie‐Christine Bouton   +8 more
doaj   +1 more source

Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline. [PDF]

Biologics
Leon F Willis,1 Nikil Kapur,2 Sheena E Radford,1 David J Brockwell1 1School of Molecular and Cellular Biology, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK; 2School of Mechanical
Willis LF, Kapur N, Radford SE, Brockwell DJ.   +3 more
europepmc   +2 more sources

Production of Therapeutic Single-Chain Variable Fragments (ScFv) in Pichia pastoris

, 2021
The interest in the use of monoclonal antibodies as therapeutic molecules has raised in the recent years. Due to their high affinity and specificity towards other biological molecules, antibodies are being widely used to treat a broad range of human ...
Montoliu-Gaya, Laia,, Sandra Villegas, Villegas, Sandra,, Laia Montoliu-Gaya   +3 more
core   +1 more source

Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa

Pharmaceutics, 2021
Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents.
Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gänger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Völk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowski   +15 more
doaj   +1 more source

Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives

Vaccines, 2021
Respiratorytract infections (RTIs) are frequent and life-threatening diseases, accounting for several millions of deaths worldwide. RTIs implicate microorganisms, including viruses (influenza virus, coronavirus, respiratory syncytial virus (RSV ...
Alexie Mayor, Adélaïde Chesnay, Guillaume Desoubeaux, David Ternant, Nathalie Heuzé-Vourc’h, Thomas Sécher   +5 more
doaj   +1 more source

Combination therapy of therapeutic antibody and vaccine or entecavir in HBV carrier mice

Frontiers in Microbiology, 2023
Chronic infection with the hepatitis B virus (HBV) is a leading causes of liver cirrhosis and hepatocellular carcinoma. However, managing HBV treatments is challenging due to the lack of effective monotherapy. Here, we present two combination approaches,
Ruoyao Qi, Ruoyao Qi, Jiali Cao, Yangtao Wu, Yangtao Wu, Xing Lei, Xing Lei, Jinhang He, Jinhang He, Liang Zhang, Liang Zhang, Rao Fu, Rao Fu, Feng Chen, Feng Chen, Yingbin Wang, Yingbin Wang, Tianying Zhang, Tianying Zhang, Ningshao Xia, Ningshao Xia, Quan Yuan   +21 more
doaj   +1 more source

Intracellular Antibodies for Drug Discovery and as Drugs of the Future

, 2023
The application of antibodies in cells was first shown in the early 1990s, and subsequently, the field of intracellular antibodies has expanded to encompass antibody fragments and their use in target validation and as engineered molecules that can be ...
Rabbitts, TH, T. H. Rabbitts
core   +1 more source

Editorial: Effector functions of therapeutic antibodies [PDF]

, 2022
Therapeutic antibodies are broadly used in both oncology and autoimmune indications. Currently there are more than hundred antibodies approved by the FDA and many more are in development.
Peipp, Matthias, Boross, Peter, Nimmerjahn, Falk   +2 more
core   +1 more source

Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses

, 2022
International audienceThe multiple mechanisms of action of antiviral monoclonal antibodies (mAbs) have made these molecules a potential therapeutic alternative for treating severe viral infections. In addition to their direct effect on viral propagation,
Mireia Pelegrin, Souchard, Manon, Naranjo-Gomez, Mar, Pelegrin, Mireia, Abba-Moussa, Daouda, Marsile-Medun, Soledad, Manon Souchard, Soledad Marsile-Medun, Mar Naranjo-Gomez, Daouda Abba-Moussa   +9 more
core   +1 more source

H-ferritin nanoparticle-mediated antibody delivery across the blood-brain barrier

Frontiers in Aging Neuroscience
BackgroundTherapeutic monoclonal antibodies (mAbs) show great promise for treating neurological disorders thanks to their high selectivity and potency. However, their clinical potential is significantly limited by poor penetration across the blood-brain ...
Ziwei Yuan, Laura Rué, Tom Jaspers, Marie-Lynn Cuypers, Maarten Dewilde, Maarten Dewilde   +5 more
doaj   +1 more source