Results 21 to 30 of about 45,745 (258)

State of play and clinical prospects of antibody gene transfer

Journal of Translational Medicine, 2017
Recombinant monoclonal antibodies (mAbs) are one of today’s most successful therapeutic classes in inflammatory diseases and oncology. A wider accessibility and implementation, however, is hampered by the high product cost and prolonged need for frequent
Kevin Hollevoet, Paul J. Declerck
doaj   +1 more source

Production of Therapeutic Single-Chain Variable Fragments (ScFv) in Pichia pastoris

, 2021
The interest in the use of monoclonal antibodies as therapeutic molecules has raised in the recent years. Due to their high affinity and specificity towards other biological molecules, antibodies are being widely used to treat a broad range of human ...
Montoliu-Gaya, Laia,, Sandra Villegas, Villegas, Sandra,, Laia Montoliu-Gaya   +3 more
core   +1 more source

Selective CNS Targeting and Distribution with a Refined Region-Specific Intranasal Delivery Technique via the Olfactory Mucosa

Pharmaceutics, 2021
Intranasal drug delivery is a promising approach for the delivery of drugs to the CNS, but too heterogenous, unprecise delivery methods without standardization decrease the quality of many studies in rodents.
Frank Maigler, Simone Ladel, Johannes Flamm, Stella Gänger, Barbara Kurpiers, Stefanie Kiderlen, Ronja Völk, Carmen Hamp, Sunniva Hartung, Sebastian Spiegel, Arghavan Soleimanizadeh, Katharina Eberle, Rebecca Hermann, Lukas Krainer, Claudia Pitzer, Katharina Schindowski   +15 more
doaj   +1 more source

Therapeutic Antibodies for the Treatment of Respiratory Tract Infections—Current Overview and Perspectives

Vaccines, 2021
Respiratorytract infections (RTIs) are frequent and life-threatening diseases, accounting for several millions of deaths worldwide. RTIs implicate microorganisms, including viruses (influenza virus, coronavirus, respiratory syncytial virus (RSV ...
Alexie Mayor, Adélaïde Chesnay, Guillaume Desoubeaux, David Ternant, Nathalie Heuzé-Vourc’h, Thomas Sécher   +5 more
doaj   +1 more source

Intracellular Antibodies for Drug Discovery and as Drugs of the Future

, 2023
The application of antibodies in cells was first shown in the early 1990s, and subsequently, the field of intracellular antibodies has expanded to encompass antibody fragments and their use in target validation and as engineered molecules that can be ...
Rabbitts, TH, T. H. Rabbitts
core   +1 more source

Combination therapy of therapeutic antibody and vaccine or entecavir in HBV carrier mice

Frontiers in Microbiology, 2023
Chronic infection with the hepatitis B virus (HBV) is a leading causes of liver cirrhosis and hepatocellular carcinoma. However, managing HBV treatments is challenging due to the lack of effective monotherapy. Here, we present two combination approaches,
Ruoyao Qi, Ruoyao Qi, Jiali Cao, Yangtao Wu, Yangtao Wu, Xing Lei, Xing Lei, Jinhang He, Jinhang He, Liang Zhang, Liang Zhang, Rao Fu, Rao Fu, Feng Chen, Feng Chen, Yingbin Wang, Yingbin Wang, Tianying Zhang, Tianying Zhang, Ningshao Xia, Ningshao Xia, Quan Yuan   +21 more
doaj   +1 more source

Anti-SARS-CoV-2 Omicron Antibodies Isolated from a SARS-CoV-2 Delta Semi-Immune Phage Display Library

Antibodies, 2022
This report describes the discovery and characterization of antibodies with potential broad SARS-CoV-2 neutralization profiles. The antibodies were obtained from a phage display library built with the VH repertoire of a convalescent COVID-19 patient who ...
Ivette Mendoza-Salazar, Keyla M. Gómez-Castellano, Edith González-González, Ramsés Gamboa-Suasnavart, Stefany D. Rodríguez-Luna, Giovanni Santiago-Casas, María I. Cortés-Paniagua, Sonia M. Pérez-Tapia, Juan C. Almagro   +8 more
doaj   +1 more source

Current perspectives on therapeutic antibodies

, 2021
Since the first monoclonal antibody, muromonab-CD3, was approved for therapeutic use in 1986, numerous molecules have been targeted using therapeutic antibody technology, resulting in 26 therapeutic antibodies being approved by the US FDA as of November,
심현보
core   +1 more source

Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs?

Frontiers in Pharmacology, 2020
Model-informed precision dosing (MIPD) software tools are used to optimize dosage regimens in individual patients, aiming to achieve drug exposure targets associated with desirable clinical outcomes.
Wannee Kantasiripitak, Ruth Van Daele, Ruth Van Daele, Matthias Gijsen, Matthias Gijsen, Marc Ferrante, Marc Ferrante, Isabel Spriet, Isabel Spriet, Erwin Dreesen, Erwin Dreesen   +10 more
doaj   +1 more source

Editorial: The immune response to therapeutic antibodies

Frontiers in Immunology
Michael G. Tovey, Arno J. Kromminga, Daniel T. Mytych   +2 more
doaj   +3 more sources