Results 31 to 40 of about 32,878,841 (350)

Deubiquitylating Enzymes in Cancer and Immunity

Advanced Science, 2023
Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome by removing the post‐translational modification ubiquitin moiety from substrates.
Jiang Ren, Peng Yu, Sijia Liu, Ran Li, Xin Niu, Yan Chen, Zhenyu Zhang, Fangfang Zhou, Long Zhang   +8 more
doaj   +1 more source

Antioxidant effect of grape seed extract corrects experimental autoimmune encephalomyelitis behavioral dysfunctions, demyelination, and glial activation

Frontiers in Immunology, 2022
Background and purposeMultiple sclerosis (MS), a multifactorial autoimmune disease of the central nervous system (CNS), is characterized by demyelination and chronic inflammation, as well as axonal and neuronal loss.
Maha Mabrouk, Maha Mabrouk, Maha Mabrouk, Maha Mabrouk, Mohamed El Ayed, Mohamed El Ayed, Amélie Démosthènes, Amélie Démosthènes, Youssef Aissouni, Youssef Aissouni, Ezzedine Aouani, Ezzedine Aouani, Laurence Daulhac-Terrail, Laurence Daulhac-Terrail, Meherzia Mokni, Meherzia Mokni, Mélina Bégou, Mélina Bégou   +17 more
doaj   +1 more source

MTAP loss: a possible therapeutic approach for glioblastoma

Journal of Translational Medicine, 2022
Glioblastoma is the most lethal form of brain tumor with a recurrence rate of almost 90% and a survival time of only 15 months post-diagnosis. It is a highly heterogeneous, aggressive, and extensively studied tumor.
C. Patro, Nupur Biswas, S. Pingle, Feng Lin, Misa Anekoji, Lawrence D. Jones, S. Kesari, Feng Wang, S. Ashili   +8 more
semanticscholar   +1 more source

Approach to the patient with metabolic syndrome in general medicine [PDF]

Opšta Medicina, 2017
Introduction: Metabolic syndrome (MS) is a collection of metabolic disorders that increase the risk of developing diabetes and cardiovascular disease and is a serious public health problem. Objective: 1.
Petrov-Kiurski Miloranka Đ.
doaj   +1 more source

Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes

Frontiers in Immunology, 2023
BackgroundImpaired wound healing is the most common and significant complication of Diabetes. While most other complications of Diabetes have better treatment options, diabetic wounds remain a burden as they can cause pain and suffering in patients ...
S. Nirenjen, J. Narayanan, T. Tamilanban, Vetriselvan Subramaniyan, Vetriselvan Subramaniyan, V. Chitra, Neeraj Kumar Fuloria, Ling Shing Wong, Gobinath Ramachawolran, Mahendran Sekar, Gaurav Gupta, Gaurav Gupta, Shivkanya Fuloria, Suresh V. Chinni, Suresh V. Chinni, Siddharthan Selvaraj   +15 more
doaj   +1 more source

The need for a strategic therapeutic approach: multiple sclerosis in check

Therapeutic Advances in Chronic Disease, 2022
Multiple sclerosis (MS) is the most common chronic autoimmune neurological disease. Its therapeutic management has drastically evolved in the recent years with the development of specific disease-modifying therapies (DMTs).
Hernan Inojosa, Undine Proschmann, K. Akgün, T. Ziemssen   +3 more
semanticscholar   +1 more source

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity

Immunologic research, 2021
The continuous emergence of infectious pathogens along with antimicrobial resistance creates a need for an alternative approach to treat infectious diseases.
K. Saikh
semanticscholar   +1 more source

Targeting AMPK by Statins: A Potential Therapeutic Approach

Drugs, 2021
Statins are a group of lipid-lowering drugs that inhibit cholesterol biosynthesis and have anti-inflammatory, anti-tumor, and immunomodulatory properties.
Sajad Dehnavi, Amirhossein Kiani, Mahvash Sadeghi, Ali Farhadi Biregani, M. Banach, S. Atkin, T. Jamialahmadi, A. Sahebkar   +7 more
semanticscholar   +1 more source

Brain stimulation: a therapeutic approach for the treatment of neurological disorders

CNS Neuroscience & Therapeutics, 2021
Brain stimulation has become one of the most acceptable therapeutic approaches in recent years and a powerful tool in the remedy against neurological diseases.
J. Camacho-Conde, Maria Del Rosario Gonzalez-Bermudez, Marta Carretero-Rey, Zafar U. Khan   +3 more
semanticscholar   +1 more source

Therapeutic approaches for shankopathies [PDF]

Developmental Neurobiology, 2013
ABSTRACTDespite recent advances in understanding the molecular mechanisms of autism spectrum disorders (ASD), the current treatments for these disorders are mostly focused on behavioral and educational approaches. The considerable clinical and molecular heterogeneity of ASD present a significant challenge to the development of an effective treatment ...
Wang, Xiaoming, Bey, Alexandra L, Chung, Leeyup, Krystal, Andrew D, Jiang, Yong‐Hui   +4 more
openaire   +4 more sources