Results 241 to 250 of about 1,472,669 (399)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Therapeutic drug monitoring of immunotherapies with novel Affimer–NanoBiT sensor construct

, 2023
Emma Campbell, Hope Adamson, Timothy Luxton, Christian Tiede, Christoph Wälti, Darren C. Tomlinson, Lars J. C. Jeuken   +6 more
openalex   +2 more sources

Evaluation of the Efficacy and Safety of Satralizumab in a Pregnant NMOSD Patient With AQP4/MOG‐IgG Dual Seropositive: A Case Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Neuromyelitis Optica Spectrum Disorder (NMOSD) is a chronic autoimmune neuroinflammatory disease, typically characterized by antibodies against aquaporin 4 (AQP4‐IgG) or myelin oligodendrocyte glycoprotein (MOG‐IgG). Simultaneous seropositivity for both antibodies in a single patient is exceedingly rare.
Yeting Luo, Shuhua Xie, Xianghong Liu
wiley   +1 more source

Therapeutic drug monitoring education: The current state. [PDF]

Br J Clin Pharmacol
Petrova G, Blagova S, Tachkov K, Santos M, Bluett J, Rumano M, Kkolou E, Drakalska E, Arev M, Barsbay MC, Mulleman D.   +10 more
europepmc   +1 more source

Therapeutic Drug Monitoring of Clozapine and Norclozapine in Human Serum Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry [PDF]

, 2009
D. S. Ming, J.G. Heathcote
openalex   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Therapeutic drug monitoring of posaconazole oral suspension in paediatric patients younger than 13 years of age: a retrospective analysis and literature review

, 2016
Timothy Jancel, Pamela A. Shaw, Claire W. Hallahan, T. Kim, Alexandra F. Freeman, Steven M. Holland, Scott Penzak   +6 more
openalex   +1 more source

Therapeutic drug monitoring

, 2018
Tuberculosis is the world’s deadliest infectious disease, and, in particular the spread of multidrug-resistance is challenging the ending of the tuberculosis pandemic. With a treatment success rate of 54% and reported untreatable forms of tuberculosis, there is a dire need to improve drug-resistant tuberculosis treatment.
openaire   +1 more source

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source

Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine

, 2017
Lisanne M. Geers, Dan Cohen, Laura M. Wehkamp, Kai van Hateren, Remco A. Koster, Olga Fedorenko, A. Semke, Н. А. Бохан, Svetlana А. Ivanova, Jos G. W. Kosterink, A.J.M. Loonen, Daan J. Touw   +11 more
openalex   +2 more sources