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Principles of therapeutic drug monitoring
Postgraduate Medicine, 1981Biochemical monitoring is generally advised for drugs that are potentially toxic, have a narrow therapeutic range, or are prescribed for life-threatening disease. Monitoring should not be attempted until the serum concentration reaches a plateau, or steady state, and sampling must be timed carefully.
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Therapeutic Drug Monitoring in Pregnancy
Therapeutic Drug Monitoring, 2012Therapeutic drug monitoring (TDM) is commonly recommended to optimize drug dosing regimens of various medications. It has been proposed to guide therapy in pregnant women, in whom physiological changes may lead to altered pharmacokinetics resulting in difficulty in predicting the appropriate drug dosage.
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Therapeutic Monitoring of Antiarrhythmic Drugs
Therapeutic Drug Monitoring, 1980Antiarrhythmic drugs are potent agents which generally have narrow therapeutic indices. The consequences of administering either too little or too much can be life-threatening. Consequently, monitoring of plasma concentrations of these agents is an important part of rational antiarrhythmic therapy.
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Antiepileptic Therapeutic Drug Monitoring
Clinics in Laboratory Medicine, 1981The effort to employ therapeutic drug monitoring in the management of patients with convulsive disorders has been extremely successful. Fortunately, the drugs used by the majority of these patients are readily measured in plasma, and in most cases the plasma concentration is a valid measure of the appropriateness of the dosage of drug administered ...
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Therapeutic drug monitoring in tuberculosis
European Journal of Clinical PharmacologyTherapeutic drug monitoring (TDM) is a standard clinical procedure that uses the pharmacokinetic and pharmacodynamic parameters of the drug in the body to determine the optimal dose. The pharmacokinetic variability of the drug(s) is a significant contributor to poor treatment outcomes, including the development of acquired drug resistance.
M, Sarkar, J, Sarkar
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Therapeutic drug monitoring in patients with tuberculosis and concurrent medical problems
Expert Opinion on Drug Metabolism and Toxicology, 2021Anne-Grete Martson +2 more
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Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects
Expert Opinion on Drug Metabolism and Toxicology, 2020Cecilie Johannessen Landmark +2 more
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