Results 51 to 60 of about 1,046,320 (355)
European Psychiatry, 2021 Pregnancy is associated with profound changes in pharmacokinetic processes. This is an important - and until recently neglected - area of research since the majority of women take drugs during pregnancy in addition to vitamin and dietary supplements ...
A. Wieck
doaj +1 more source
Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy: A 2018 Update
Therapeutic Drug Monitoring, 2018 Background: Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Since 1989, 18 new AEDs have been licensed for clinical use and there are now 27 licensed AEDs in total for the treatment of patients with epilepsy.
P. Patsalos, E. P. Spencer, D. Berry
semanticscholar +1 more source
Therapeutic Drug Monitoring, 2019 Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality of bioanalytical methods, the design, development and validation needs to fit the intended use.
S. Capiau +13 more
semanticscholar +1 more source
Gülhane Tıp Dergisi, 2022 Aims:Gentamicin is routinely used in neonates as an empirical antibiotic for suspected sepsis at a dose of 4.0 mg/kg, either 24 or 36 hourly based on premenstrual age. Regularly, therapeutic drug monitoring is performed.
Suzana Mustafa +3 more
doaj +1 more source
Antibiotics, 2021 Isavuconazole (ISZ) is used in the treatment of aspergillosis and mucormycosis. The purpose of this study was to evaluate the therapeutic drug monitoring (TDM) of ISZ samples from a clinical setting performed at Statens Serum Institut. Materials/methods:
Malene Risum +5 more
doaj +1 more source
Predicting tacrolimus exposure in kidney transplanted patients using machine learning [PDF]
arXiv, 2022 Tacrolimus is one of the cornerstone immunosuppressive drugs in most transplantation centers worldwide following solid organ transplantation. Therapeutic drug monitoring of tacrolimus is necessary in order to avoid rejection of the transplanted organ or severe side effects.
arxiv
Therapeutic Drug Monitoring in Inflammatory Bowel Disease
Journal of Coloproctology, 2023 Inflammatory bowel disease (IBD) is a problem that directly affects the quality of life of patients suffering from this condition. Monitoring the serum level of infliximab (IFX) (TDM) is an important tool for guiding therapeutic decisions in IBD patients.
Manoel Alvaro de Freitas Lins Neto +6 more
doaj +1 more source
BMC Gastroenterology, 2022 Backgrounds Optimal concentration of ustekinumab (UST) predicting endoscopic remission has not been fully investigated in Crohn’s disease (CD). We aimed to identify the optimal UST trough levels predicting clinical, laboratory and endoscopic remission in
Hisashi Hirayama +7 more
doaj +1 more source
A clustering and graph deep learning-based framework for COVID-19 drug repurposing [PDF]
arXiv, 2023 Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other diseases. This involves analyzing the interactions between different biological entities, such as drug targets ...
arxiv
The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib
Frontiers in Pharmacology, 2020 Pharmacometric methods have hugely benefited from progress in analytical and computer sciences during the past decades, and play nowadays a central role in the clinical development of new medicinal drugs.
T. Buclin +6 more
semanticscholar +1 more source