Results 51 to 60 of about 1,472,669 (399)

Therapeutic drug monitoring of immunosuppressant drugs [PDF]

British Journal of Clinical Pharmacology, 1999
Individualizing a patient’s drug therapy to obtain the optimum balance between therapeutic efficacy and the occurrence of adverse events is the physician’s goal. However, achieving this goal is not always straight forward, being complicated by within and between patient variability in both pharmacokinetics and pharmacodynamics.
A, Johnston, D W, Holt
openaire   +2 more sources

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients

Journal of Intensive Care, 2018
Background Analgosedation is a cornerstone therapy for mechanically ventilated patients in intensive care units (ICU). To avoid inadequate sedation and its complications, monitoring of analgosedation is of great importance.
Richard J. Nies, Carsten Müller, Roman Pfister, Philipp S. Binder, Nicole Nosseir, Felix S. Nettersheim, Kathrin Kuhr, Martin H. J. Wiesen, Matthias Kochanek, Guido Michels   +9 more
doaj   +1 more source

Therapeutic drug monitoring (TDM) of atazanavir in pregnancy [PDF]

, 2012
Purpose of the study: Pregnant women experience physiological changes during pregnancy resulting in clinically significant alterations in antiretroviral pharmacokinetics (PK).
D Back, J Breiden, J Lambert, L Else, M Brennan, M Lawless, S Coulter Smith, S Khoo, V Jackson   +8 more
core   +1 more source

Therapeutic Drug Monitoring of Antibiotics Is Needed in the Treatment of Sepsis

Вестник анестезиологии и реаниматологии, 2022
The article presents the results of a prospective one-center observational clinical study.The level of therapeutic drug monitoring antibiotics was studied in patients with sepsis.The objective: to assess the impact of pharmacokinetics and ...
G. P. Plotnikov, A. N. Kudryavtsev, A. A. Kleuzovich, A. G. Chizhov, A. A. Ponomarev, S. S. Larin, E. A. Litvin, L. A. Anastasevich   +7 more
doaj   +1 more source

Therapeutic drug monitoring in drug overdose [PDF]

British Journal of Clinical Pharmacology, 1999
The treatment of poisoned patients is still largely defined by history, clinical assessment and interpretation of ancillary investigations. Measurement of drug concentrations is clinically important for relatively few compounds. Most measurements form an adjunct to and should not be considered a substitute for clinical assessment.
A H, Dawson, I M, Whyte
openaire   +5 more sources

Biosensor‐Enabled Multiplexed On‐Site Therapeutic Drug Monitoring of Antibiotics

Advances in Materials, 2021
Personalized antibiotherapy ensures that the antibiotic concentration remains in the optimal therapeutic window to maximize efficacy, minimize side effects, and avoid the emergence of drug resistance due to insufficient dosing.
H. Ates, H. Mohsenin, Christin Wenzel, Regina T. Glatz, H. J. Wagner, Richard Bruch, Nico Hoefflin, S. Spassov, Lea Streicher, S. Lozano-Zahonero, Bernd Flamm, R. Trittler, Martin J. Hug, M. Köhn, Johannes Schmidt, S. Schumann, Gerald A. Urban, W. Weber, C. Dincer   +18 more
semanticscholar   +1 more source

Meropenem use and therapeutic drug monitoring in clinical practice: a literature review

Journal of Clinical Pharmacy and Therapeutics, 2021
Meropenem, a carbapenem antibiotic, is widely prescribed for the treatment of life‐threatening infections. The main parameter associated with its therapeutic success is the percentage of time that the levels remain above the minimum inhibitory ...
N. A. Steffens, E. Zimmermann, S. M. Nichelle, Natália Brucker   +3 more
semanticscholar   +1 more source

Personalizing HIV therapy, mission impossible? [PDF]

, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source

Clinical consequences of antibody formation, serum concentrations, and HLA-Cw6 status in psoriasis patients on Ustekinumab [PDF]

, 2019
Background: Ustekinumab for the treatment of psoriasis is currently administered in a standard dosing regimen. However, some patients tend to benefit from alternative dosing regimens, a step toward personalized medicine.
Busard, Celine, I, Costanzo, Antonio, De Keyser, Eline, Hutten, Barbara A., Lambert, Jo, Lanssens, Sven, Meuleman, Lieve, Spuls, Phyllis, I, van den Reek, Juul M., Zweegers, Jeffrey   +9 more
core   +1 more source