Results 51 to 60 of about 1,376,471 (276)

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

Ganciclovir therapeutic drug monitoring in transplant recipients

Journal of Antimicrobial Chemotherapy, 2021
Background The use of (val)ganciclovir is complicated by toxicity, slow response to treatment and acquired resistance. Objectives To evaluate a routine therapeutic drug monitoring (TDM) programme for ganciclovir in a transplant patient population ...
A. Märtson, A. E. Edwina, J. Burgerhof, S. Berger, A. D. de Joode, K. Damman, E. Verschuuren, H. Blokzijl, Martijn Bakker, L. Span, T. S. van der Werf, D. Touw, M. Sturkenboom, M. Knoester, J. C. Alffenaar   +14 more
semanticscholar   +1 more source

Therapeutic Drug Monitoring of Antibiotics Is Needed in the Treatment of Sepsis

Вестник анестезиологии и реаниматологии, 2022
The article presents the results of a prospective one-center observational clinical study.The level of therapeutic drug monitoring antibiotics was studied in patients with sepsis.The objective: to assess the impact of pharmacokinetics and ...
G. P. Plotnikov, A. N. Kudryavtsev, A. A. Kleuzovich, A. G. Chizhov, A. A. Ponomarev, S. S. Larin, E. A. Litvin, L. A. Anastasevich   +7 more
doaj   +1 more source

Therapeutic drug monitoring (TDM) of atazanavir in pregnancy [PDF]

, 2012
Purpose of the study: Pregnant women experience physiological changes during pregnancy resulting in clinically significant alterations in antiretroviral pharmacokinetics (PK).
D Back, J Breiden, J Lambert, L Else, M Brennan, M Lawless, S Coulter Smith, S Khoo, V Jackson   +8 more
core   +1 more source

Pharmacologic Treatment of Transplant Recipients Infected With SARS-CoV-2: Considerations Regarding Therapeutic Drug Monitoring and Drug–Drug Interactions

Therapeutic Drug Monitoring, 2020
Background: COVID-19 is a novel infectious disease caused by the severe acute respiratory distress (SARS)-coronavirus-2 (SARS-CoV-2). Several therapeutic options are currently emerging but none with universal consensus or proven efficacy.
L. Elens, L. Langman, D. Hesselink, S. Bergan, D. Moes, M. Molinaro, R. Venkataramanan, F. Lemaitre   +7 more
semanticscholar   +1 more source

Therapeutic drug monitoring of oral targeted antineoplastic drugs

European Journal of Clinical Pharmacology, 2020
This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM).
Anna Mueller‐Schoell, S. Groenland, Oliver Scherf-Clavel, M. van Dyk, W. Huisinga, R. Michelet, U. Jaehde, N. Steeghs, A. Huitema, C. Kloft   +9 more
semanticscholar   +1 more source

Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy: A 2018 Update

Therapeutic Drug Monitoring, 2018
Background: Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Since 1989, 18 new AEDs have been licensed for clinical use and there are now 27 licensed AEDs in total for the treatment of patients with epilepsy.
P. Patsalos, E. P. Spencer, D. Berry
semanticscholar   +1 more source

Clinical consequences of antibody formation, serum concentrations, and HLA-Cw6 status in psoriasis patients on Ustekinumab [PDF]

, 2019
Background: Ustekinumab for the treatment of psoriasis is currently administered in a standard dosing regimen. However, some patients tend to benefit from alternative dosing regimens, a step toward personalized medicine.
Busard, Celine, I, Costanzo, Antonio, De Keyser, Eline, Hutten, Barbara A., Lambert, Jo, Lanssens, Sven, Meuleman, Lieve, Spuls, Phyllis, I, van den Reek, Juul M., Zweegers, Jeffrey   +9 more
core   +1 more source

Official International Association for Therapeutic Drug Monitoring and Toxicology guideline: Development and Validation of Dried Blood Spot-based Methods for Therapeutic Drug Monitoring.

Therapeutic Drug Monitoring, 2019
Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality of bioanalytical methods, the design, development and validation needs to fit the intended use.
S. Capiau, Herman Veenhof, R. Koster, Y. Bergqvist, M. Boettcher, O. Halmingh, B. Keevil, B. Koch, R. Linden, C. Pistos, L. Stolk, D. Touw, C. Stove, J. Alffenaar   +13 more
semanticscholar   +1 more source

Monitoring of gentamicin blood level in one-week-of-life neonates admitted to a special care nursery ward

Gülhane Tıp Dergisi, 2022
Aims:Gentamicin is routinely used in neonates as an empirical antibiotic for suspected sepsis at a dose of 4.0 mg/kg, either 24 or 36 hourly based on premenstrual age. Regularly, therapeutic drug monitoring is performed.
Suzana Mustafa, Siti Latifah Azirah Mohd Noor, Rozitah Razman, Wan Nazirah Wan Yusuf   +3 more
doaj   +1 more source