Results 81 to 90 of about 18,835 (320)

Using a hypothetical scenario to assess public preferences for colorectal surveillance following screening-detected, intermediate-risk adenomas: annual home-based stool test vs. triennial colonoscopy [PDF]

, 2016
Background To assess public preferences for colorectal cancer (CRC) surveillance tests for intermediate-risk adenomas, using a hypothetical scenario. Methods Adults aged 45–54 years without CRC were identified from three General Practices in England (two
Atkin, W, Bonello, B, Bowyer, HL, Ghanouni, A, Halloran, SP, MacRae, E, Von Wagner, C, Wardle, J   +7 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Patients’ beliefs about generic medicines in Malaysia

Pharmacy Practice, 2014
Background: Acceptance of generic medicines by patients is an essential factor given that they are the end users of these medicines. In fact, adequate knowledge and positive perceptions are prerequisite to patients’ acceptance and use of generic ...
Wong ZY, Hassali MA, Alrasheedy AA, Saleem F, Yahaya AH, Aljadhey H   +5 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Generic antihypertensive medications with therapeutic interchangeability requirements [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2019
Señor Editor: La hipertensión arterial (HTA) es el factor de riesgo cardiovascular más prevalente y causa de muerte prematura a nivel mundial. Según Organización Mundial de la Salud (OMS) la HTA provoca 7,5 millones de muertes al año, que equivale al ...
Giulianna Gamero-Vega, Percy Ocampo-Rujel   +1 more
doaj  

The Controversy Over Generic Equivalency of Drugs [PDF]

, 1967
The truth about generic equivalency has not yet been determined. The arguments in the generic equivalency controversy are confounded by names, proprietary (trademark, brand name) as opposed to non-proprietary (generic, branded-generic), yet quality of ...
Lowenthal, Werner
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Multisource drug policies in Latin America: survey of 10 countries

Bulletin of the World Health Organization, 2005
Essential drug lists and generic drug policies have been promoted as strategies to improve access to pharmaceuticals and control their rapidly escalating costs.
Homedes Núria, Ugalde Antonio
doaj  

Development of the Japanese version of the 30‐item Mystical Experience Questionnaire

Neuropsychopharmacology Reports
Introduction Psychedelics have garnered increased attention as potential therapeutic options for various mental illnesses. Previous studies reported that psychedelics cause psychoactive effects through mystical experiences induced by these substances ...
Kengo Yonezawa, Hideaki Tani, Shinichiro Nakajima, Hiroyuki Uchida   +3 more
doaj   +1 more source

A multi-center interventional study to assess pharmacokinetics, effectiveness, and tolerability of prolonged-release tacrolimus after pediatric kidney transplantation: study protocol for a prospective, open-label, randomized, two-phase, two-sequence, single dose, crossover, phase III b trial

Frontiers in Nephrology
BackgroundTacrolimus, a calcineurin inhibitor (CNI), is currently the first-line immunosuppressive agent in kidney transplantation. The therapeutic index of tacrolimus is narrow due to due to the substantial impact of minor variations in drug ...
Sinem Karaterzi, Burkhard Tönshoff, Thurid Ahlenstiel-Grunow, Maral Baghai, Maral Baghai, Bodo Beck, Anja Büscher, Lisa Eifler, Thomas Giese, Susanne Lezius, Carsten Müller, Jun Oh, Antonia Zapf, Lutz T. Weber, Lars Pape   +14 more
doaj   +1 more source