Results 111 to 120 of about 2,567,854 (328)

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

The Protective Role and Mechanism of Mild Therapeutic Hypothermia Protection on Brain Cells

Neuropsychiatric Disease and Treatment, 2023
Suixin Liang,1 Yunxing Ti,2 Xiuhong Li,1 Wenjia Zhou1 1Department of CICU, Shenzhen Children’s Hospital, Shenzhen City, Guangdong Province, People’s Republic of China; 2Department of Cardiothoracic Surgery, Shenzhen Children’s Hospital, Shenzhen City ...
Liang S, Ti Y, Li X, Zhou W
doaj  

Anaesthesia and Intensive Care [PDF]

, 2004
The anaesthetist has seen his role steadily expand and it is hard to think of one medical specialty in which anaesthetists are not involved at least to some extent.
Aquilina, Andrew, Sciberras, Stephen C.
core  

Preclinical discovery of duloxetine for the treatment of depression [PDF]

, 2012
Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María, Elorza, Julián, Micó Segura, Juan Antonio, Perez-Caballero, Laura, Torres-Sanchez, Sonia   +4 more
core   +2 more sources

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia

Neonatology, 2019
Background: Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450
Laurent M A Favié, F. Groenendaal, M. V. D. van den Broek, C. Rademaker, T. D. de Haan, Henrica L. M. van Straaten, P. Dijk, A. V. van Heijst, S. Simons, K. Dijkman, M. Rijken, I. Zonnenberg, F. Cools, A. Zecic, J. H. van der Lee, D. Nuytemans, F. van Bel, T. Egberts, A. Huitema   +18 more
semanticscholar   +1 more source

The association of umbilical cord blood neurofilament light with non‐reassuring fetal status: A prospective observational study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Early detection of hypoxic–ischemic encephalopathy (HIE) in neonates is critical. We conducted a pilot cohort study to determine the feasibility of collecting umbilical cord blood samples for neurofilament light (NfL) and to assess the association of NfL with non‐reassuring fetal status and other cord biomarkers. We aimed to address (
David Zalcberg, Kaitlin Kramer, Emma Payne, Thomas Payne, Shreeya Marathe, Neha Mahajan, Ashly Liu, Jessica Barry, Andrew Duckworth, Mitchell Brooks, Bradley de Vries, Fernando Gonzalez‐Ortiz, Kaj Blennow, Henrik Zetterberg, Adrienne Gordon, Benjamin Moran, Helen J. Manning, Robert D. Sanders   +17 more
wiley   +1 more source

Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. [PDF]

, 2019
BackgroundNeonatal seizures are associated with adverse neurologic sequelae including epilepsy in childhood. Here we aim to determine whether levels of cytokines in neonates with brain injury are associated with acute symptomatic seizures or remote ...
Barkovich, A James, Deng, Xutao, Ferriero, Donna M, Foster-Barber, Audrey, Glass, Hannah C, Numis, Adam L, Rogers, Elizabeth E   +6 more
core  

Abdominal trauma in dogs 2. management [PDF]

, 2018
Trauma represents a big challenge for emergency doctors both in human and veterinary medicine. There have been great advancements in trauma medicine in people and these often provide an inspiration for veterinary surgeons.
Cortellini, S, Humm, K R
core   +1 more source

Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease.

Current Medicinal Chemistry, 2019
Therapeutic hypothermia has consistently been shown to be a robust neuroprotectant in many labs studying different models of neurological disease. Although this therapy has shown great promise, there are still challenges at the clinical level that limit ...
K. Kurisu, Jong Youl Kim, Jesung You, M. Yenari   +3 more
semanticscholar   +1 more source

External cephalic version outcomes with tocolysis and sedation: A 10‐year retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate the effectiveness and safety of external cephalic version (ECV) performed with tocolysis and sedation or spinal anesthesia, and to identify predictors of ECV success, complications, and delivery outcomes after successful ECV. Methods This 10‐year cohort study included 990 pregnant women with term non‐cephalic presentation
Javier Sánchez‐Romero, Rosa María Gallego‐Pozuelo, José Eliseo Blanco‐Carnero, Javier Herrera‐Giménez, Fernando Araico‐Rodríguez, Alberto Rafael Guijarro‐Campillo, Aníbal Nieto‐Díaz, Catalina de Paco‐Matallana   +7 more
wiley   +1 more source