Results 31 to 40 of about 2,567,854 (328)

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]

, 2015
Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D, Bainbridge, A, Cady, E, Charles-Edwards, G, Deierl, A, Edwards, AD, Fagiolo, G, Franks, NP, Griffiths, J, Hajnal, J, Juszczak, E, Kapetanakis, B, Linsell, L, Maze, M, Omar, O, Robertson, NJ, Strohm, B, Tusor, N   +17 more
core   +2 more sources

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

A novel ECG-biomarker for cardiac arrest during hypothermia

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2020
Background Treatment of arrhythmias evoked by accidental or therapeutic hypothermia and rewarming remains challenging. We aim to find an ECG-biomarker that can predict ventricular arrhythmias at temperatures occurring in therapeutic and accidental ...
Erik Sveberg Dietrichs, Torkjel Tveita, Rachel Myles, Godfrey Smith   +3 more
doaj   +1 more source

Combination treatments with therapeutic hypothermia for hypoxic‐ischemic neuroprotection

Developmental Medicine & Child Neurology, 2020
Therapeutic hypothermia is now proven to reduce death or disability in term and near‐term born infants with moderate to severe hypoxic‐ischemic encephalopathy.
Kelly Q. Zhou, J. Davidson, L. Bennet, A. Gunn   +3 more
semanticscholar   +1 more source

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Mediators of Inflammation, 2015
Background. The deterioration of hemodynamics instantly endangers the patients’ life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the ...
Matthias Weuster, Philipp Mommsen, Roman Pfeifer, Juliane Mohr, Steffen Ruchholtz, Sascha Flohé, Matthias Fröhlich, Claudia Keibl, Andreas Seekamp, Martijn van Griensven, Ingo Witte   +10 more
doaj   +1 more source

A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates

Frontiers in Pharmacology, 2020
Therapeutic hypothermia (TH) is standard treatment for neonates (≥36 weeks) with perinatal asphyxia (PA) and hypoxic–ischemic encephalopathy. TH reduces mortality and neurodevelopmental disability due to reduced metabolic rate and decreased neuronal ...
A. Smits, P. Annaert, S. V. Van Cruchten, K. Allegaert   +3 more
semanticscholar   +1 more source

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

Liver Transplantation, EarlyView., 2022
Abstract End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for liver transplantation (LT). However, its results in the setting of significant (≥30%) macrovesicular steatosis (MaS) have not been specifically assessed.
Damiano Patrono, Riccardo De Carlis, Alessandro Gambella, Francesca Farnesi, Alice Podestà, Andrea Lauterio, Francesco Tandoi, Luciano De Carlis, Renato Romagnoli   +8 more
wiley   +1 more source

Dexmedetomidine for Sedation of Neonates with HIE Undergoing Therapeutic Hypothermia: A Single-Center Experience

American Journal of Perinatology Reports, 2018
Hypoxic-ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality in neonates. Therapeutic hypothermia reduces the risk of death or disability.
Keliana O'Mara, Michael D. Weiss
doaj   +1 more source

Therapeutic hypothermia and cardiac intervention after cardiac arrest in pregnancy with underlying maternal arrhythmia: A case report

Case Reports in Women's Health, 2020
There are few case reports of utilization of therapeutic hypothermia during pregnancy, and most report successful maternal and fetal outcomes. There is no available evidence that supports withholding therapeutic hypothermia in these patients.
James P. Hogg, III, Lorene Atkins Temming, Rebecca Pollack   +2 more
doaj   +1 more source

Effectiveness of therapeutic hypothermia for mild neonatal encephalopathy

Medicine, 2022
. Background:. Neonates with moderate to severe encephalopathy benefit significantly from therapeutic hypothermia, with reduced risk of death or disability.
Tingting Zheng, MB, Xini Liu, MB, Xuechun Chen, MB   +2 more
doaj   +1 more source