Results 171 to 180 of about 1,137,024 (297)

Potential Biomarker and Therapeutic Tools for Pathological Cardiac Hypertrophy and Heart Failure: Extracellular Vesicles. [PDF]

Int J Mol Sci
Sun J, Zhou D, Cheng M.
europepmc   +1 more source

Apoptotic MSCs and MSC-Derived Apoptotic Bodies as New Therapeutic Tools. [PDF]

Curr Issues Mol Biol, 2022
Kholodenko IV, Kholodenko RV, Majouga AG, Yarygin KN.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sensory Processing Disorders in Children and Adolescents: Taking Stock of Assessment and Novel Therapeutic Tools. [PDF]

Brain Sci, 2022
Passarello N, Tarantino V, Chirico A, Menghini D, Costanzo F, Sorrentino P, Fucà E, Gigliotta O, Alivernini F, Oliveri M, Lucidi F, Vicari S, Mandolesi L, Turriziani P.   +13 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Overview of extracellular vesicles as biomarkers and therapeutic tools in pediatric diseases: focus on the gut-lung axis. [PDF]

Extracell Vesicles Circ Nucl Acids
Bisaccia P, Zaramella A, Hochuli AHD, Diaz RM, Duci M, Muraca M, Baraldi E, Pozzobon M.   +7 more
europepmc   +1 more source

The Role of miRNAs as Therapeutic Tools in Sickle Cell Disease. [PDF]

Medicina (Kaunas), 2021
Cyrus C.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

STING-targeting PROTACs: emerging therapeutic tools for enhanced immunotherapy in inflammatory diseases. [PDF]

Front Immunol
Jiang W, Yang X, Liu H, Wang C, Niu H, Yu W.   +5 more
europepmc   +1 more source

In silico structure-based design of peptides or proteins as therapeutic tools for obesity or diabetes mellitus: A protocol for systematic review and meta analysis. [PDF]

Medicine (Baltimore), 2023
Medeiros I, Aguiar AJFC, Fortunato WM, Teixeira AFG, Oliveira E Silva EG, Bezerra IWL, Maia JKDS, Piuvezam G, Morais AHA.   +8 more
europepmc   +1 more source