Results 91 to 100 of about 1,970,330 (303)

Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis

Advanced Materials, EarlyView.
Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne, Julian S. Hertel, André Delavault, Judith Felk, Martin Peng, Lara Reuber, Felix Ott, Kim Wanner, Marc F. Münker, Adrian Neukirch, Alexei Kiselev, Kersten S. Rabe, Christof M. Niemeyer   +12 more
wiley   +1 more source

Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development

, 2008
[[abstract]]Enterovirus 71 (EV71) is an enterovirus that could lead to severe neurological disorders and fatalities. The inactivated vaccine is an appropriate EV71 vaccine format for meeting current needs.
Wu, SC; Liu, CC; Lian, WC
core   +1 more source

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference. [PDF]

, 2010
EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated research program in the field of HIV vaccines ...
Palma, Paolo, Palma Paolo, Lara Mainetti, Paolo Palma, Grupping, K., Reudelsterz, M., Robin Shattock, Hannes Uchtenhagen, Gabriella Scarlatti, Hallengärd, D, Uchtenhagen, H, Hallengärd David, Shattock Robin, Caroline Weber, Mainetti, Lara, Wahren, Britta, Winni De Haes, Coleman, A., Annette Sköld, Seifried, Janna, Sköld, A, Sköld Annette, Scarlatti, G, Lund University., Selhorst, P., Hornig Julia, van Gils, M. J., De Haes, W., Hornig, Julia, De Haes, W, Klein, K., Seifried Janna, Biswas, P., Da Costa, K., Da Costa Kelly, Da Costa, K, De Haes, Winni, Dieltjens Tessa, Wahren, B., Reudelsterz, Marc, Palma, P., Borggren, Marie,, Dispinseri Stefania, Seifried, J., Uchtenhagen, Hannes, Hornig, J., Borggren, Marie, Da Costa, Kelly, Scarlatti Gabriella, Selhorst, P, Wahren, B, Selhorst Philippe, David Hallengärd, Kelly Da Costa, Katrijn Grupping, Priscilla Biswas, Shattock, R., Katja Klein, Mainetti Lara, Mainetti, L., Janna Seifried, Dieltjens, Tessa, Scarlatti, Gabriella, Klein Katja, Marit J van Gils, Weber, Caroline, Weber, C, De Haes Winni, Uchtenhagen Hannes, Grupping Katrijn, van Gils, M.J., Borggren Marie, Adam Coleman, Weber Caroline, Shattock, R, Hornig, J, van Gils Marit J, Marie Borggren, Borggren, M, Selhorst, Philippe, Costa, Kelly Da, Mainetti, L, Skold, A., Biswas, P, Coleman, Adam, Coleman, A, Stefania Dispinseri, Gils, Marit J. van, Palma, P, Wahren Britta, Marc Reudelsterz, Hallengard, David, Seifried, J, Haes, Winni De, van Gils, MJ, Weber, C., Scarlatti, G., Philippe Selhorst, Biswas Priscilla, Reudelsterz, M, van Gils, Marit J., Klein, K, Hallengard, D., Britta Wahren, Tessa Dieltjens, Borggren, M., Dieltjens, T., Coleman Adam, Grupping, K, Biswas, Priscilla, Skold, Annette, Grupping, Katrijn, Dispinseri, S., Dieltjens, T, Dispinseri, S, Klein, Katja, Reudelsterz Marc, Julia Hornig, Dispinseri, Stefania, Shattock, Robin   +119 more
core   +2 more sources

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Nucleos(t)ide Analog–Therapeutic Vaccination Switch: A Novel Approach for Safe and Effective Treatment Discontinuation in HBeAg (-) Chronic Hepatitis B Patients

Vaccines
Background/Objective: Long-term nucleos(t)ide analog (NUC) therapy effectively suppresses hepatitis B virus (HBV) replication, but it rarely achieves a functional cure and typically requires lifelong administration.
Sheikh Mohammad Fazle Akbar, Mamun Al Mahtab, Mohammad Abdur Rahim, Sheikh Mohammad Noor-E-Alam, Musarrat Mahtab, Ahmed Lutful Moben, Rokshana Begum, Dulal Chandra Das, Gerardo Guillen, Osamu Yoshida, Ivan Santos Martinez, Yoichi Hiasa, Sakirul Khan, Julio Cesar Aguilar   +13 more
doaj   +1 more source

Incidence of narcolepsy before and after MF59-adjuvanted influenza A(H1N1)pdm09 vaccination in South Korean soldiers

, 2015
BACKGROUND: Previous reports mostly from Europe suggested an association between an occurrence of narcolepsy and an influenza A(H1N1)pdm09 vaccine adjuvanted with AS03 (Pandemrix(®)).
이은, 남궁기
core   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine

, 2013
[[abstract]]AbstractBackground Large-scale outbreaks of enterovirus 71 (EV71) infections have occurred in Asia-Pacific regions. Severe complications include encephalitis and poliomyelitis-like paralysis, cardiopulmonary collapse, and death, necessitating
Cheng, A;Fung, CP;Liu, CC;Lin, YT;Tsai, HY;Chang, SC;Chou, AH;Chang, JY;Jiang, RH;Hsieh, YC;Su, IJ;Chong, PCS;Hsieh, SM
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source