Results 121 to 130 of about 3,300,951 (351)
Vaccines, 2015 Tumor vaccine design requires prediction and validation of immunogenic MHC class I epitopes expressed by target cells as well as MHC class II epitopes expressed by antigen-presenting cells essential for the induction of optimal immune responses.
Peng Peng Ip +2 more
doaj +1 more source
Outlook Magazine, Winter 2018 [PDF]
, 2018 https://digitalcommons.wustl.edu/outlook/1206/thumbnail ...
core +1 more source
Therapeutic Vaccine for Lymphoma
Yonsei Medical Journal, 2007 The unique antigenic determinants (Idiotype [Id]) of the immunoglobulin expressed on a given B-cell malignancy can serve as a tumor-specific antigen for active immunotherapy. Therapeutic vaccines targeting the tumor-specific idiotype have demonstrated promising results against lymphomas in phase I/II studies and are currently being evaluated in phase ...
Lee, Seung-Tae +2 more
openaire +2 more sources
Nature Nanotechnology, 2020 Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), which can substantially increase the risk of developing liver disease.
Wenjun Wang +12 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu +3 more
wiley +1 more source
Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review [PDF]
, 2018 Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with ...
Biankin, Andrew V. +3 more
core +1 more source
A Bayesian design for phase I cancer therapeutic vaccine trials
Statistics in Medicine, 2018 Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage.
Chenguang Wang, G. Rosner, R. Roden
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Lipid nanoparticles containing messenger RNA are characterized by sedimentation velocity analytical ultracentrifugation using UltraScan's new Custom Grid algorithm to provide multi‐dimensional distributions for partial specific volume (particle density), molar mass, sedimentation, diffusion, and hydrodynamic radius.
Sophia Bird +8 more
wiley +1 more source
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]
, 2019 BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G +14 more
core
Cancer immunology research, 2018 A nanoparticle-based long peptide vaccine activates CD8+ T cells and improves therapeutic efficacy in mouse models of HPV-driven cancer. This strategy may be effective in enhancing responses in other solid tumors, suggesting its potential for clinical ...
Gabriele Galliverti +7 more
semanticscholar +1 more source