Results 21 to 30 of about 3,300,951 (351)

Therapeutic cancer vaccines [PDF]

Journal of Clinical Investigation, 2015
The clinical benefit of therapeutic cancer vaccines has been established. Whereas regression of lesions was shown for premalignant lesions caused by HPV, clinical benefit in cancer patients was mostly noted as prolonged survival. Suboptimal vaccine design and an immunosuppressive cancer microenvironment are the root causes of the lack of cancer ...
Melief, C.J.M., Hall, T. van, Arens, R., Ossendorp, F., Burg, S.H. van der   +4 more
openaire   +3 more sources

Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]

, 2010
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin, Hara, Eiichi, Homma, Sadamu, Koido, Shigeo, Namiki, Yoshihisa, Ohkusa, Toshifumi, Tajiri, Hisao   +6 more
core   +11 more sources

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

bioRxiv, 2023
Here we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV carrier mouse models generated by viral vector-mediated HBV transfection (pAAV-HBV1.2 and rAAV8-HBV1.3), this
Huajun Zhao, Xianyu Shao, Yating Yu, Lulu Huang, Narh Philip Amor, Kun Guo, Changzhen Weng, Weijun Zhao, Ailu Yang, Jiesen Hu, Hongbao Yang, Zhenguang Liu, Qiuju Han, Leilei Shi, Shiyu Sun, Jian Zhang, Yong Yang, Ang Lin   +17 more
semanticscholar   +1 more source

Therapeutic Cancer Vaccines [PDF]

, 2014
Therapeutic cancer vaccines have the potential of being integrated in the therapy of numerous cancer types and stages. The wide spectrum of vaccine platforms and vaccine targets is reviewed along with the potential for development of vaccines to target cancer cell "stemness," the epithelial-to-mesenchymal transition (EMT) phenotype, and drug-resistant ...
Jeffrey, Schlom, James W, Hodge, Claudia, Palena, Kwong-Yok, Tsang, Caroline, Jochems, John W, Greiner, Benedetto, Farsaci, Ravi A, Madan, Christopher R, Heery, James L, Gulley   +9 more
openaire   +2 more sources

Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine

Journal for ImmunoTherapy of Cancer, 2020
Background While prophylactic human papillomavirus (HPV) vaccines will certainly reduce the incidence of HPV-associated cancers, these malignancies remain a major health issue. PDS0101 is a liposomal-based HPV therapeutic vaccine consisting of the immune
Claire Smalley Rumfield, S. Pellom, Y. Morillon II, J. Schlom, C. Jochems   +4 more
semanticscholar   +1 more source

Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs

Viruses, 2023
Herpes simplex virus type 2 (HSV-2) is a leading cause of genital ulcer disease and a major risk factor for acquisition and transmission of HIV. Frequent recurrent genital lesions and concerns about transmitting infection to intimate partners affect the ...
Sita Awasthi, Motoyasu Onishi, John M. Lubinski, Bernard T. Fowler, Alexis M. Naughton, Lauren M. Hook, Kevin P. Egan, Masaki Hagiwara, Seiki Shirai, Akiho Sakai, Takayuki Nakagawa, Kumiko Goto, Osamu Yoshida, Alisa J. Stephens, Grace Choi, Gary H. Cohen, Kazufumi Katayama, Harvey M. Friedman   +17 more
doaj   +1 more source

Antitumor effect of therapeutic HPV DNA vaccines with chitosan-based nanodelivery systems [PDF]

, 2014
Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors.
Atyabi, F., Ghaemi, A., Gorji, A., Kalhor, H.R., Kelishadi, M., Moradi, A., Sajadian, A., Tabarraei, A., Tahamtan, A.   +8 more
core   +3 more sources

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-titer HBV Carrier Mice.

Gastroenterology, 2020
BACKGROUND & AIMS Hepatitis B virus (HBV) infection persists because the virus-specific immune response is dysfunctional. Therapeutic vaccines might be used to end immune tolerance to the virus in patients with chronic infection, but these have not been ...
T. Michler, A. Kosinska, J. Festag, T. Bunse, Jinpeng Su, M. Ringelhan, Hortenzia Imhof, D. Grimm, K. Steiger, C. Mogler, M. Heikenwalder, M. Michel, C. Guzmán, S. Milstein, L. Sepp-Lorenzino, P. Knolle, U. Protzer   +16 more
semanticscholar   +1 more source

Vaccine development for pathogenic fungi: current status and future directions

Expert Review of Vaccines, 2023
Introduction Fungal infections are caused by a broad range of pathogenic fungi that are found worldwide with different geographic distributions, incidences, and mortality rates. Considering that there are relatively few approved medications available for
Jéssica L. Chechi, Felipe A. C. da Costa, Julia M. Figueiredo, Cássia M. de Souza, Alessandro F. Valdez, Daniel Zamith-Miranda, Aline C. Camara, Carlos P. Taborda, Joshua D. Nosanchuk   +8 more
doaj   +1 more source

Roadblocks to translational challenges on viral pathogenesis. [PDF]

, 2013
Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven, Drosten, Christian, Picker, Louis, Subbarao, Kanta, Suzich, Joann   +4 more
core   +1 more source