Results 231 to 240 of about 1,969,671 (301)

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

Angewandte Chemie, EarlyView.
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng, Tyson D. Todd, Alexandria L. Quillin, Harshad Ingle, Angela M. Halstead, Megan T. Baldridge, José B. Sáenz, Jennifer M. Heemstra   +7 more
wiley   +2 more sources

"A great step in treating cervical cancer": Patient and provider perceptions about cervical cancer therapeutic vaccines. [PDF]

Patient Educ Couns
Whitmer A, Fuzzell LN, Lowery S, Arevalo M, Rathwell J, Arredondo B, Mason AL, Geiss C, Giuliano A, Vadaparampil ST.   +9 more
europepmc   +1 more source

Synthetic Particulate Subunit Vaccines Co‐Delivering Multiple Antigens Induce Protective Immunity Against Melioidosis

Advanced NanoBiomed Research, EarlyView.
Engineered endotoxin‐free Escherichia coli were used to assemble poly(3‐hydroxybutyrate) (PHB) biopolymer particles displaying multiple conserved Burkholderia pseudomallei antigens via PhaC‐mediated surface presentation. Following formulation with poly(I:C), the particulate vaccines induced antigen‐specific humoral and cellular immune responses ...
Md. Tanvir Kabir, Shuxiong Chen, Justine B. Bendo, Ashley Johnson, Aleksandra W. Debowski, Mitali Sarkar‐Tyson, Bernd H. A. Rehm   +6 more
wiley   +1 more source

Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

Angewandte Chemie, EarlyView.
Several green‐emitting fluorogenic RNA aptamers were evaluated following the replacement of every uridine by N1‐methylpseudouridine (mΨ). Because this modification impaired the function of most aptamers, a directed evolution strategy combining droplet microfluidics, bioinformatics, and rational design was used to identify an aptamer preserving its ...
Patrick P.A. Bertrand, Roger Cubi, Claire Husser, Magali Frugier, Michael Ryckelynck   +4 more
wiley   +2 more sources

Preclinical Immunogenicity and Efficacy Studies for Therapeutic Vaccines for Human Papillomavirus-Type-16-Associated Cancer. [PDF]

Vaccines (Basel)
Mohammadi M, Saha A, Giles-Davis W, Xiang Z, Novikov M, Hasanpourghadi M, C J Ertl H.   +6 more
europepmc   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +2 more sources

Current status of immunological therapies for rheumatoid arthritis with a focus on antigen-specific therapeutic vaccines. [PDF]

Front Immunol
Zimmerman DH, Szekanecz Z, Markovics A, Rosenthal KS, Carambula RE, Mikecz K.   +5 more
europepmc   +1 more source

Risk of autoimmunity, cancer seeding, and adverse events in human trials of whole-tissue autologous therapeutic vaccines. [PDF]

Cancer Pathog Ther
Gianneschi G, Scolpino A, Oleske J.
europepmc   +1 more source

Efficacy and safety of therapeutic vaccines for the treatment of chronic hepatitis B: A systematic review and meta-analysis of randomized controlled trials update. [PDF]

Medicine (Baltimore)
Geta M, Geta M, Mengistu G, Yizengaw E, Manyzewal T, Hailu A, Woldeamanuel Y.   +6 more
europepmc   +1 more source